PMID- 6659594
OWN - NLM
STAT- MEDLINE
DCOM- 19840223
LR  - 20191023
IS  - 0044-264X (Print)
IS  - 0044-264X (Linking)
VI  - 22
IP  - 4
DP  - 1983 Dec
TI  - [Biliary excretion of choleretically active cinnamic acid derivatives in the 
      rat].
PG  - 255-70
AB  - Concerning the well-known choleretic effect of ferulic acid, we made further 
      investigations on biliary excretion, metabolism and bile flow after application 
      of ferulic acid and related compounds. In anesthesized bile duct cannulated male 
      Wistar-rats, we studied the biliary excretion of the following 14-C labelled 
      cinnamic acid compounds: caffeic acid (CA), ferulic acid (FA), m-coumaric acid 
      (mCA), p-coumaric acid (pCA), isoferulic acid (IFA), p-methoxycinnamic acid 
      (pMCA), 3,4-dimethoxycinnamic acid (DMCA), and 3,4,5-trimethoxycinnamic acid 
      (TMCA). These compounds were given intraduodenally (128-384 mumoles/kg b. wt.). 
      All of the tested compounds were excreted to some extent in bile, giving a bile 
      to the serum conc. ratio greater than 1. The radioactivity excreted by bile 
      within 2 hours (as percent of the given dose) was about 20% in the case of FA, 
      IFA, DMCA, and TMCA, about 8% for pMCA, and less than 5% for CA, mCA and pCA. The 
      biliary excretion increased in a dose-dependent manner only after FA and IFA, but 
      not after application of the other compounds.
FAU - Westendorf, J
AU  - Westendorf J
FAU - Czok, G
AU  - Czok G
LA  - ger
PT  - Journal Article
TT  - Die biliare Ausscheidung choleretisch aktiver Zimtsaure-Derivate durch die Ratte.
PL  - Germany
TA  - Z Ernahrungswiss
JT  - Zeitschrift fur Ernahrungswissenschaft
JID - 0413632
RN  - 0 (Caffeic Acids)
RN  - 0 (Cholagogues and Choleretics)
RN  - 0 (Cinnamates)
RN  - 0 (Coumaric Acids)
RN  - AVM951ZWST (ferulic acid)
SB  - IM
MH  - Animals
MH  - Bile/*metabolism
MH  - Caffeic Acids/metabolism
MH  - Cholagogues and Choleretics/*metabolism
MH  - Cinnamates/administration & dosage/*metabolism
MH  - Coumaric Acids/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Intubation, Gastrointestinal
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Structure-Activity Relationship
MH  - Time Factors
EDAT- 1983/12/01 00:00
MHDA- 1983/12/01 00:01
CRDT- 1983/12/01 00:00
PHST- 1983/12/01 00:00 [pubmed]
PHST- 1983/12/01 00:01 [medline]
PHST- 1983/12/01 00:00 [entrez]
AID - 10.1007/BF02023858 [doi]
PST - ppublish
SO  - Z Ernahrungswiss. 1983 Dec;22(4):255-70. doi: 10.1007/BF02023858.