PMID- 6664241
OWN - NLM
STAT- MEDLINE
DCOM- 19840302
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 33 Suppl 1
DP  - 1983
TI  - Parallel distribution of methionine-enkephalin-Arg6-Gly7-Leu8 with 
      methionine-enkephalin, leucine-enkephalin and methionine-enkephalin-Arg6-Phe7 in 
      human and bovine brains.
PG  - 65-8
AB  - Using specific radioimmunoassays(RIAs) for methionine-enkephalin(Met-Enk), 
      leucine-enkephalin(Leu-Enk), methionine-enkephalin-Arg6-Gly7-Leu8 
      (Met-Enk-Arg-Gly-Leu) and methionine-enkephalin-Arg6-Phe7 (Met-Enk-Arg-Phe), we 
      studied the regional distribution of these opioid peptides in human and bovine 
      brains. Met-Enk-Arg-Gly-Leu was distributed in parallel with Met-Enk, Leu-Enk and 
      Met-Enk-Arg-Phe in human and bovine brains. The ratios of molar concentrations of 
      these peptides are almost constant in various regions of human and bovine brains 
      and similar to the ratio of these peptides contained in preproenkephalin A. Gel 
      exclusion chromatography and HPLC coupled with respective RIAs showed the 
      existence of authentic peptides without any detectable high molecular weight 
      forms. These results indicate the parallel distribution of Met-Enk-Arg-Gly-Leu 
      with Met-Enk, Leu-Enk and Met-Enk-Arg-Phe in various regions of human and bovine 
      brains and further suggest that these opioid peptides are derived from the same 
      precursor as that in the adrenal medulla and that the processing of 
      preproenkephalin A is almost complete in human and bovine brains.
FAU - Ikeda, Y
AU  - Ikeda Y
FAU - Nakao, K
AU  - Nakao K
FAU - Yoshimasa, T
AU  - Yoshimasa T
FAU - Sakamoto, M
AU  - Sakamoto M
FAU - Suda, M
AU  - Suda M
FAU - Yanaihara, N
AU  - Yanaihara N
FAU - Imura, H
AU  - Imura H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 58569-55-4 (Enkephalin, Methionine)
RN  - 58822-25-6 (Enkephalin, Leucine)
RN  - 73024-95-0 (enkephalin-Met, Arg(6)-Phe(7)-)
RN  - 80501-44-6 (enkephalin-Met, Arg(6)-Gly(7)-Leu(8)-)
SB  - IM
MH  - Animals
MH  - *Brain Chemistry
MH  - Cattle
MH  - Chromatography, High Pressure Liquid
MH  - Enkephalin, Leucine/*analysis
MH  - Enkephalin, Methionine/*analogs & derivatives/*analysis
MH  - Humans
MH  - Species Specificity
EDAT- 1983/01/01 00:00
MHDA- 1983/01/01 00:01
CRDT- 1983/01/01 00:00
PHST- 1983/01/01 00:00 [pubmed]
PHST- 1983/01/01 00:01 [medline]
PHST- 1983/01/01 00:00 [entrez]
AID - 10.1016/0024-3205(83)90445-9 [doi]
PST - ppublish
SO  - Life Sci. 1983;33 Suppl 1:65-8. doi: 10.1016/0024-3205(83)90445-9.