PMID- 6664459
OWN - NLM
STAT- MEDLINE
DCOM- 19840302
LR  - 20190726
IS  - 0028-3908 (Print)
IS  - 0028-3908 (Linking)
VI  - 22
IP  - 11
DP  - 1983 Nov
TI  - Interaction between renin-angiotensin system and cholinergic system in brain.
PG  - 1269-75
AB  - Intracerebroventricular (i.c.v.) injection of hemicholinium-3 (HC-3; 20 
      micrograms), which depletes acetylcholine stores in brain, reduced the increase 
      in mean arterial pressure (MAP) and the drinking, but not the decrease in heart 
      rate (HR), induced by intraventricular injection of angiotensin II (ANG II, 50 
      and 100 ng) in conscious rats. Intraventricular injection of atropine (up to 1 
      microgram) decreased only the pressor effect, while larger doses (up to 10 
      micrograms) decreased the bradycardia, too. Mecamylamine (100 micrograms i.c.v.) 
      reduced the pressor response induced by angiotensin, without influencing the 
      decrease in heart rate. A dose of 50 micrograms of mecamylamine had no effect. 
      Neither atropine (10 micrograms i.c.v.) nor mecamylamine (50 micrograms i.c.v.) 
      affected thirst induced by angiotensin. Intravenous (i.v.) atropine, but not 
      atropine methylbromide, strongly reduced the drinking effect. The increase in 
      arterial pressure and the decrease in heart rate induced by intraventricular 
      injection of physostigmine, as well as the drinking behaviour after carbachol 
      (250 ng, i.c.v.) or the increase in arterial pressure following intravenous 
      injection of physostigmine (in methylatropine-pretreated rats), were not 
      influenced by either saralasin (up to 10 micrograms/kg, i.c.v.) or captopril (up 
      to 50 micrograms, i.c.v.). These results suggest that: (1) the increase in mean 
      arterial pressure and drinking behaviour, induced by intraventricular injection 
      of angiotensin II, are partially mediated via acetylcholine in brain, acting 
      through muscarinic receptors; (2) decrease in heart rate induced by angiotensin 
      II is not baroreceptor reflex-mediated; (3) the brain renin-angiotensin system 
      does not participate in the cardiovascular and behavioural effect induced by 
      cholinergic stimulation in the brain.
FAU - Nicoletta, P
AU  - Nicoletta P
FAU - Pochiero, M
AU  - Pochiero M
FAU - Losi, E
AU  - Losi E
FAU - Caputi, A P
AU  - Caputi AP
LA  - eng
PT  - Journal Article
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 11128-99-7 (Angiotensin II)
RN  - 8Y164V895Y (Carbachol)
SB  - IM
MH  - Angiotensin II/pharmacology
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Brain/drug effects/*physiology
MH  - Carbachol/pharmacology
MH  - Drinking Behavior/drug effects
MH  - Heart Rate/drug effects
MH  - Injections, Intraventricular
MH  - Male
MH  - Parasympathetic Nervous System/drug effects/*physiology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - *Renin-Angiotensin System/drug effects
EDAT- 1983/11/01 00:00
MHDA- 1983/11/01 00:01
CRDT- 1983/11/01 00:00
PHST- 1983/11/01 00:00 [pubmed]
PHST- 1983/11/01 00:01 [medline]
PHST- 1983/11/01 00:00 [entrez]
AID - 10.1016/0028-3908(83)90199-5 [doi]
PST - ppublish
SO  - Neuropharmacology. 1983 Nov;22(11):1269-75. doi: 10.1016/0028-3908(83)90199-5.