PMID- 6667557
OWN - NLM
STAT- MEDLINE
DCOM- 19840416
LR  - 20190919
IS  - 0730-0077 (Print)
IS  - 0730-0077 (Linking)
VI  - 5
IP  - 10
DP  - 1983
TI  - Effect of the intracerebroventricular injection of dopamine on blood pressure in 
      the spontaneously hypertensive rat.
PG  - 1703-16
AB  - To examine the role of the central dopaminergic system in blood pressure 
      regulation, dopamine was injected into the cerebral lateral ventricles of 
      conscious, unrestrained spontaneously hypertensive rats (SHR), 
      deoxycorticosterone (DOC)-salt hypertensive rats and Wistar-Kyoto normotensive 
      rats (WKY). Intracerebroventricular (i.c.v.) injection of dopamine produced a 
      significant dose-dependent decrease in blood pressure in the SHR as well as in 
      the WKY and DOC-salt hypertensive rats. However, the SHR were significantly more 
      sensitive than were the other 2 groups of rats. In the SHR, this central 
      depressor effect of dopamine was significantly attenuated by pretreatment with 
      i.c.v. metoclopramide, but not by phentolamine, suggesting that central dopamine 
      receptors rather than alpha-adrenoceptors are involved in the mediation of the 
      actions of dopamine in the brain. These results suggest that the central 
      dopaminergic system plays a more important role in the regulation of blood 
      pressure in the SHR than in the WKY and DOC-salt hypertensive rats.
FAU - Kawabe, H
AU  - Kawabe H
FAU - Kondo, K
AU  - Kondo K
FAU - Saruta, T
AU  - Saruta T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Clin Exp Hypertens A
JT  - Clinical and experimental hypertension. Part A, Theory and practice
JID - 8207790
RN  - 0 (Dopamine Antagonists)
RN  - 0 (Receptors, Dopamine)
RN  - 40GP35YQ49 (Desoxycorticosterone)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - L4YEB44I46 (Metoclopramide)
RN  - VTD58H1Z2X (Dopamine)
RN  - Z468598HBV (Phentolamine)
SB  - IM
MH  - Animals
MH  - Blood Pressure/*drug effects
MH  - Desoxycorticosterone
MH  - Dopamine/*administration & dosage/pharmacology
MH  - Dopamine Antagonists
MH  - Dose-Response Relationship, Drug
MH  - Hypertension/chemically induced/*physiopathology
MH  - Injections, Intraventricular
MH  - Male
MH  - Metoclopramide/pharmacology
MH  - Phentolamine/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Dopamine/physiology
MH  - Sodium Chloride
EDAT- 1983/01/01 00:00
MHDA- 1983/01/01 00:01
CRDT- 1983/01/01 00:00
PHST- 1983/01/01 00:00 [pubmed]
PHST- 1983/01/01 00:01 [medline]
PHST- 1983/01/01 00:00 [entrez]
AID - 10.3109/10641968309051803 [doi]
PST - ppublish
SO  - Clin Exp Hypertens A. 1983;5(10):1703-16. doi: 10.3109/10641968309051803.