PMID- 6667710
OWN - NLM
STAT- MEDLINE
DCOM- 19840329
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 95
IP  - 1-2
DP  - 1983 Nov 11
TI  - Proanaphylactic action of morphine is mediated through a central cholinergic 
      mechanism.
PG  - 117-9
AB  - Intracerebroventricular (i.c.v.) or intravenous (i.v.) administration of morphine 
      (10 micrograms or 25 mg/kg, respectively) increased the mortality rate in 
      experimental anaphylaxis in mice. This effect was blocked by the opiate 
      antagonist naltrexone administered systemically (5 mg/kg) or i.c.v. (10 
      micrograms). Moreover, the effect of morphine was blocked by i.c.v. 
      administration of the muscarine antagonist methyl atropine (10 micrograms). The 
      systemic administration of 5 mg/kg methyl atropine was ineffective in blocking 
      the action of morphine. The results suggest that the proanaphylactic effect of 
      morphine involves activation of cholinergic mechanisms in the central nervous 
      system.
FAU - Amir, S
AU  - Amir S
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Atropine Derivatives)
RN  - 5S6W795CQM (Naltrexone)
RN  - 76I7G6D29C (Morphine)
RN  - 80719I460H (methylatropine)
SB  - IM
MH  - Anaphylaxis/*physiopathology
MH  - Animals
MH  - Atropine Derivatives/pharmacology
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Morphine/antagonists & inhibitors/*toxicity
MH  - Naltrexone/pharmacology
MH  - Parasympathetic Nervous System/*drug effects
EDAT- 1983/11/11 00:00
MHDA- 2000/06/01 09:00
CRDT- 1983/11/11 00:00
PHST- 1983/11/11 00:00 [pubmed]
PHST- 2000/06/01 09:00 [medline]
PHST- 1983/11/11 00:00 [entrez]
AID - 0014-2999(83)90274-1 [pii]
AID - 10.1016/0014-2999(83)90274-1 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1983 Nov 11;95(1-2):117-9. doi: 10.1016/0014-2999(83)90274-1.