PMID- 6679216
OWN - NLM
STAT- MEDLINE
DCOM- 19841002
LR  - 20141120
IS  - 0003-9926 (Print)
IS  - 0003-9926 (Linking)
VI  - 143
IP  - 5
DP  - 1983 May
TI  - Iron deficiency and sickle cell anemia.
PG  - 1030-2
AB  - In a patient with sickle cell anemia, iron deficiency was accompanied by 
      hypochromic, microcytic RBCs, absence of bone marrow iron, and a low serum 
      ferritin level. The mean corpuscular hemoglobin concentration (MCHC) was 
      decreased (27.6 g/dL) and was associated with an extreme scarcity of sickled 
      erythrocytes in blood smears. Iron therapy resulted in reticulocytosis and an 
      increase in sickled erythrocytes. In vitro studies demonstrated a decrease in 
      sickling of erythrocytes as a function of oxygen saturation of the blood when the 
      patient was iron deficient. The whole blood oxygen dissociation curve showed a 
      substantial decrease in oxygen pressure necessary to produce 50% saturation of 
      hemoglobin at pH 7.4 and 37 degrees C (P50), indicating an increased oxygen 
      affinity. These data suggest that a reduction of the MCHC induced by iron 
      deficiency may ameliorate sickling.
FAU - Rao, K R
AU  - Rao KR
FAU - Patel, A R
AU  - Patel AR
FAU - Honig, G R
AU  - Honig GR
FAU - Vida, L N
AU  - Vida LN
FAU - McGinnis, P R
AU  - McGinnis PR
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Arch Intern Med
JT  - Archives of internal medicine
JID - 0372440
RN  - 0 (Ferrous Compounds)
RN  - 0 (Hemoglobin, Sickle)
RN  - 39R4TAN1VT (ferrous sulfate)
RN  - 9007-73-2 (Ferritins)
RN  - 9034-51-9 (Hemoglobin A)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Anemia, Hypochromic/blood/*complications/drug therapy
MH  - Anemia, Sickle Cell/blood/*complications
MH  - Bacterial Infections/complications
MH  - Ferritins/blood
MH  - Ferrous Compounds/therapeutic use
MH  - Hemoglobin A/analysis
MH  - Hemoglobin, Sickle/analysis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxygen/blood
MH  - Postoperative Complications
EDAT- 1983/05/01 00:00
MHDA- 1983/05/01 00:01
CRDT- 1983/05/01 00:00
PHST- 1983/05/01 00:00 [pubmed]
PHST- 1983/05/01 00:01 [medline]
PHST- 1983/05/01 00:00 [entrez]
PST - ppublish
SO  - Arch Intern Med. 1983 May;143(5):1030-2.