PMID- 6683070
OWN - NLM
STAT- MEDLINE
DCOM- 19830708
LR  - 20190626
IS  - 0002-8703 (Print)
IS  - 0002-8703 (Linking)
VI  - 105
IP  - 6
DP  - 1983 Jun
TI  - Two forms of hypertrophic cardiomyopathy distinguished by inheritance of HLA 
      haplotypes and left ventricular outflow tract obstruction.
PG  - 988-94
AB  - In this study we have performed human leukocyte antigen (HLA)-A and B typing on 
      nine patients with hypertrophic cardiomyopathy (HCM) and their relatives. Four 
      patients had relatives who also had the disease. HLA typing of the familial form 
      of HCM revealed a very close association of a given HLA-A,B haplotype with the 
      occurrence of the disease. All four patients who had affected relatives had 
      obstruction of left ventricular outflow (LVOT), while four patients with 
      unaffected relatives did not have obstruction. One additional patient with 
      obstruction and without familial incidence was an only child and had few living 
      relatives. Thus, HCM can be divided into two subtypes: a familial form linked to 
      the HLA-A,B system, which may be related to obstructive type, and a sporadic form 
      not linked to HLA antigens. These data confirm the existence of at least two 
      separate forms of hypertrophic cardiomyopathy. The study also confirms their 
      existence in the Japanese population, with a completely different gene pool than 
      the population from the southeastern United States in whom the observation was 
      initially described.
FAU - Kishimoto, C
AU  - Kishimoto C
FAU - Kaburagi, T
AU  - Kaburagi T
FAU - Takayama, S
AU  - Takayama S
FAU - Yokoyama, S
AU  - Yokoyama S
FAU - Hanyu, I
AU  - Hanyu I
FAU - Takatsu, Y
AU  - Takatsu Y
FAU - Tomimoto, K
AU  - Tomimoto K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am Heart J
JT  - American heart journal
JID - 0370465
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cardiomyopathy, Hypertrophic/diagnosis/diagnostic imaging/*genetics
MH  - Child
MH  - Echocardiography
MH  - Electrocardiography
MH  - Female
MH  - Genotype
MH  - HLA Antigens/*analysis/genetics
MH  - Heart/diagnostic imaging
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pedigree
MH  - Radiography
EDAT- 1983/06/01 00:00
MHDA- 1983/06/01 00:01
CRDT- 1983/06/01 00:00
PHST- 1983/06/01 00:00 [pubmed]
PHST- 1983/06/01 00:01 [medline]
PHST- 1983/06/01 00:00 [entrez]
AID - 0002-8703(83)90401-5 [pii]
AID - 10.1016/0002-8703(83)90401-5 [doi]
PST - ppublish
SO  - Am Heart J. 1983 Jun;105(6):988-94. doi: 10.1016/0002-8703(83)90401-5.