PMID- 6686132
OWN - NLM
STAT- MEDLINE
DCOM- 19840214
LR  - 20190829
IS  - 0301-5548 (Print)
IS  - 0301-5548 (Linking)
VI  - 52
IP  - 1
DP  - 1983
TI  - Enzymatic adaptations to treadmill training in skeletal muscle of young and old 
      rats.
PG  - 69-74
AB  - The activities of lactic dehydrogenase (LDH), hexokinase (HK), citrate synthetase 
      (CS), and 3-hydroacyl CoA dehydrogenase (HAD), were measured in Soleus and 
      extensor digitorum longus (EDL) muscles of four different age groups of male 
      Wistar rats. Young rats (3 months) and old rats (24 months) were trained during 
      12 weeks by a 3 days a week running exercises session. Each training session was 
      of 2 h. All the enzymatic activities increased between 3 and 6 months in both 
      Soleus and EDL muscles. During aging (6-27 months) Soleus showed about the same 
      percent decrease in enzymatic activities (30%) for the four enzymes studied. In 
      contrast with Soleus, CS activity of EDL increased with age but HK, LDH, and HAD 
      decreased. The training induced an improvement of all enzymatic activities, 
      except for LDH, which decreased with training in same cases. In the old group the 
      training effect was more important than in the young group. When the relative 
      enzymatic activities were compared it was found that Soleus muscle keeps its 
      energy supply enzyme pattern during aging, whereas EDL evolutes to a more 
      oxidative metabolism. Moreover old skeletal muscle remains trainable and training 
      induces an enzymatic adaptation which follows the same pattern in both muscles: 
      an increase of HK, CS, and HAD activities and a decrease of LDH.
FAU - Sanchez, J
AU  - Sanchez J
FAU - Bastien, C
AU  - Bastien C
FAU - Monod, H
AU  - Monod H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Eur J Appl Physiol Occup Physiol
JT  - European journal of applied physiology and occupational physiology
JID - 0410266
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
RN  - EC 1.14.19.- (Fatty Acid Desaturases)
RN  - EC 2.3.3.1 (Citrate (si)-Synthase)
RN  - EC 2.7.1.1 (Hexokinase)
SB  - IM
MH  - *Aging
MH  - Animals
MH  - Citrate (si)-Synthase/analysis
MH  - Fatty Acid Desaturases/analysis
MH  - Hexokinase/analysis
MH  - L-Lactate Dehydrogenase/analysis
MH  - Male
MH  - Muscles/*enzymology
MH  - *Physical Exertion
MH  - Rats
EDAT- 1983/01/01 00:00
MHDA- 1983/01/01 00:01
CRDT- 1983/01/01 00:00
PHST- 1983/01/01 00:00 [pubmed]
PHST- 1983/01/01 00:01 [medline]
PHST- 1983/01/01 00:00 [entrez]
AID - 10.1007/BF00429028 [doi]
PST - ppublish
SO  - Eur J Appl Physiol Occup Physiol. 1983;52(1):69-74. doi: 10.1007/BF00429028.