PMID- 6687841
OWN - NLM
STAT- MEDLINE
DCOM- 19830715
LR  - 20190720
IS  - 0008-8749 (Print)
IS  - 0008-8749 (Linking)
VI  - 77
IP  - 2
DP  - 1983 Apr 15
TI  - The effect of corticosteroids upon the number and organ distribution of 
      "background" immunoglobulin-secreting cells in mice.
PG  - 308-17
AB  - The influence of the synthetic corticosteroid dexamethasone sodium phosphate 
      (DEXA) upon the immunoglobulin (Ig)-secreting cells was studied in not 
      intentionally immunized BALB/c mice. This was done for IgM-, IgG-, and 
      IgA-secreting cells in spleen, mesenteric lymph nodes (MLN), and bone marrow 
      (BM). A single injection of DEXA (16 to 144 mg/kg body wt) markedly reduced the 
      number of Ig-secreting cells in spleen and MLN within 1 day, but hardly affected 
      their number in the BM. The decrease was immediately followed by a recovery and, 
      at the highest doses and especially in MLN, by an overshoot. Two weeks after the 
      initial decrease a second decrease was found. When mice were subjected to daily 
      treatment with DEXA during 1 week, initially a recovery pattern was found in 
      spleen and MLN similar to that found after a single injection of a high dose. In 
      this case, however, the effects were less dose dependent, and the overshoot 
      reaction was followed by a period of subnormal numbers of Ig-secreting cells 
      which lasted at least 1 week. This late effect of DEXA not only occurred in 
      spleen and MLN, but also in the BM. The most prominent effect of daily treatment 
      with DEXA was the long-lasting decrease of the number of IgG-secreting cells 
      starting 1 week after withdrawal of treatment. This decrease was associated with 
      a severely decreased serum IgG level.
FAU - Sabbele, N R
AU  - Sabbele NR
FAU - van Oudenaren, A
AU  - van Oudenaren A
FAU - Benner, R
AU  - Benner R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Cell Immunol
JT  - Cellular immunology
JID - 1246405
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 0 (Immunoglobulins)
RN  - 2BP70L44PR (dexamethasone 21-phosphate)
RN  - 7S5I7G3JQL (Dexamethasone)
SB  - IM
MH  - Animals
MH  - Antibody-Producing Cells/*drug effects
MH  - Bone Marrow/immunology
MH  - Bone Marrow Cells
MH  - Cell Count
MH  - Dexamethasone/*analogs & derivatives/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Immunoglobulin A/biosynthesis
MH  - Immunoglobulin G/biosynthesis
MH  - Immunoglobulin M/biosynthesis
MH  - Immunoglobulins/*biosynthesis
MH  - Lymph Nodes/cytology/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Spleen/cytology/immunology
MH  - Time Factors
EDAT- 1983/04/15 00:00
MHDA- 1983/04/15 00:01
CRDT- 1983/04/15 00:00
PHST- 1983/04/15 00:00 [pubmed]
PHST- 1983/04/15 00:01 [medline]
PHST- 1983/04/15 00:00 [entrez]
AID - 0008-8749(83)90031-X [pii]
AID - 10.1016/0008-8749(83)90031-x [doi]
PST - ppublish
SO  - Cell Immunol. 1983 Apr 15;77(2):308-17. doi: 10.1016/0008-8749(83)90031-x.