PMID- 6689057
OWN - NLM
STAT- MEDLINE
DCOM- 19840127
LR  - 20190726
IS  - 0028-3908 (Print)
IS  - 0028-3908 (Linking)
VI  - 22
IP  - 10
DP  - 1983 Oct
TI  - Changes in nociception after intrathecal administration of 
      5,6-dihydroxytryptamine in mice.
PG  - 1197-201
AB  - Intrathecal administration of 5,6-dihydroxytryptamine (5,6-DHT) (5 micrograms) to 
      mice selectively lesioned descending serotonergic pathways, reducing spinal 
      levels of 5-hydroxytryptamine (5-HT) by 80%, without significantly changing the 
      levels of noradrenaline. Increased sensitivity to noxious stimulation, as 
      measured by the tail-flick and hot-plate tests, was observed 2 days after 
      injection of 5,6-DHT. The tail-flick latencies returned to normal on day 6, but 
      were again reduced by administration of the 5-HT receptor blocker metergoline, 
      suggesting that the normalization process involved compensatory mechanisms in the 
      remaining 5-HT system. In the hot-plate test, the latencies both to shaking or 
      kicking of a hindpaw (kick) and to hindpaw lick were recorded, but the time 
      course for the changes of these two responses was found to be different. The 
      latencies to hindpaw lick were normalized within 2 weeks, whereas the hindpaw 
      kick latencies remained reduced throughout the 21 day observation period.
FAU - Fasmer, O B
AU  - Fasmer OB
FAU - Berge, O G
AU  - Berge OG
FAU - Walther, B
AU  - Walther B
FAU - Hole, K
AU  - Hole K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 333DO1RDJY (Serotonin)
RN  - W2QY253O8S (5,6-Dihydroxytryptamine)
SB  - IM
MH  - 5,6-Dihydroxytryptamine/administration & dosage/*pharmacology
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Injections, Spinal
MH  - Male
MH  - Mice
MH  - Nociceptors/*drug effects
MH  - Reaction Time/drug effects
MH  - Serotonin/metabolism
MH  - Spinal Cord/metabolism
EDAT- 1983/10/01 00:00
MHDA- 1983/10/01 00:01
CRDT- 1983/10/01 00:00
PHST- 1983/10/01 00:00 [pubmed]
PHST- 1983/10/01 00:01 [medline]
PHST- 1983/10/01 00:00 [entrez]
AID - 10.1016/0028-3908(83)90081-3 [doi]
PST - ppublish
SO  - Neuropharmacology. 1983 Oct;22(10):1197-201. doi: 10.1016/0028-3908(83)90081-3.