PMID- 6689152
OWN - NLM
STAT- MEDLINE
DCOM- 19840214
LR  - 20181113
IS  - 0378-7966 (Print)
IS  - 0378-7966 (Linking)
VI  - 8
IP  - 3
DP  - 1983 Jul-Sep
TI  - Propantheline bromide plasma level, urinary excretion and pharmacological data in 
      a comparison of the bioavailability of three oral formulations of Pro-Banthine.
PG  - 219-24
AB  - To determine the comparative bioavailability of three oral formulations of 
      propantheline bromide (PB) by both pharmacokinetic and pharmacodynamic 
      parameters, six normal men received three standard Pro-Banthine 15 mg tablets, 
      two prolonged acting (PA) Pro-Banthine 30 mg tablets or one developmental PA 
      Pro-Banthine 45 mg capsule, in a study of balanced random crossover design. 
      Plasma concentrations and urinary excretion of the unchanged drug were measured 
      after each treatment using a stable isotope dilution assay. Salivary secretion 
      rate and heart rate measurements were also made at intervals after each 
      medication. The standard Pro-Banthine formulation was significantly more 
      bioavailable, weight for weight, than either the developmental PA capsule (45 
      mg), p less than 0.05, or the two 30 mg PA tablets (60 mg), p less than 0.01, 
      based on urinary excretion and plasma levels of PB and on salivary secretion and 
      heart rate data. There was no evidence of significant prolonged action for the PA 
      formulations.
FAU - Rigby, G V
AU  - Rigby GV
FAU - Vose, C W
AU  - Vose CW
FAU - Haskins, N J
AU  - Haskins NJ
FAU - Allan, E F
AU  - Allan EF
FAU - Harrison, I R
AU  - Harrison IR
FAU - Shelton, J R
AU  - Shelton JR
FAU - Brownsill, R D
AU  - Brownsill RD
FAU - Perkins, R M
AU  - Perkins RM
FAU - Ford, G C
AU  - Ford GC
FAU - Hawkins, A J
AU  - Hawkins AJ
AU  - et al.
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - France
TA  - Eur J Drug Metab Pharmacokinet
JT  - European journal of drug metabolism and pharmacokinetics
JID - 7608491
RN  - 0 (Capsules)
RN  - 0 (Tablets)
RN  - 1306V2B0Q8 (Propantheline)
SB  - IM
MH  - Adult
MH  - Biological Availability
MH  - Capsules
MH  - Humans
MH  - Kinetics
MH  - Male
MH  - Propantheline/*administration & dosage/metabolism/pharmacology
MH  - Pulse/drug effects
MH  - Salivation/drug effects
MH  - Tablets
EDAT- 1983/07/01 00:00
MHDA- 1983/07/01 00:01
CRDT- 1983/07/01 00:00
PHST- 1983/07/01 00:00 [pubmed]
PHST- 1983/07/01 00:01 [medline]
PHST- 1983/07/01 00:00 [entrez]
AID - 10.1007/BF03188751 [doi]
PST - ppublish
SO  - Eur J Drug Metab Pharmacokinet. 1983 Jul-Sep;8(3):219-24. doi: 
      10.1007/BF03188751.