PMID- 6693069
OWN - NLM
STAT- MEDLINE
DCOM- 19840312
LR  - 20190829
IS  - 0270-9139 (Print)
IS  - 0270-9139 (Linking)
VI  - 4
IP  - 1
DP  - 1984 Jan-Feb
TI  - The effect of bile duct obstruction on the clearance of circulating IgA immune 
      complexes.
PG  - 96-100
AB  - The clearance of circulating IgA immune complexes following acute bile duct 
      obstruction was investigated in this study. IgA immune complexes were formed in 
      vitro from MOPC-315, an IgA M-component with anti-dinitrophenyl (DNP) 
      specificity, and 125I-DNP10 bovine serum albumin (BSA). Eighteen hours after 
      laparotomy during which the common bile duct was either identified only or 
      identified and ligated, the IgA immune complexes were injected intravenously. 
      Groups of bile duct-ligated and bile duct-patent rats were also injected 
      intravenously with IgG anti-DNP-125I-DNP10BSA immune complexes and 125I-bovine 
      liver beta-glucuronidase to assess the hepatic clearance of materials not 
      dependent on an intact biliary system. Clearance of IgA immune complexes was 
      delayed after bile duct ligation. Although the clearance of IgA immune complexes 
      was delayed, only 10% of these complexes remained in the circulation at 3 hr. The 
      clearance of IgG immune complexes and beta-glucuronidase was not affected by 
      ligation. These experiments demonstrate the physiologic importance of a patent 
      bile duct in the normal clearance of IgA immune complexes in the rat. The 
      observation that clearance is delayed, but not completely inhibited by bile duct 
      ligation suggests that alternate mechanisms exist for removing IgA immune 
      complexes from the circulation.
FAU - Harmatz, P R
AU  - Harmatz PR
FAU - Kleinman, R E
AU  - Kleinman RE
FAU - Bunnell, B W
AU  - Bunnell BW
FAU - McClenathan, D T
AU  - McClenathan DT
FAU - Walker, W A
AU  - Walker WA
FAU - Bloch, K J
AU  - Bloch KJ
LA  - eng
GR  - AM-21505/AM/NIADDK NIH HHS/United States
GR  - GM 21700/GM/NIGMS NIH HHS/United States
GR  - HD 12437/HD/NICHD NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Hepatology
JT  - Hepatology (Baltimore, Md.)
JID - 8302946
RN  - 0 (Antigen-Antibody Complex)
RN  - 0 (Blood Proteins)
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - EC 3.2.1.31 (Glucuronidase)
SB  - IM
MH  - Animals
MH  - Antigen-Antibody Complex/*metabolism
MH  - Blood Proteins/metabolism
MH  - Cholestasis/*immunology
MH  - Female
MH  - Glucuronidase/metabolism
MH  - Immunoglobulin A/*metabolism
MH  - Immunoglobulin G/metabolism
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1984/01/01 00:00
MHDA- 1984/01/01 00:01
CRDT- 1984/01/01 00:00
PHST- 1984/01/01 00:00 [pubmed]
PHST- 1984/01/01 00:01 [medline]
PHST- 1984/01/01 00:00 [entrez]
AID - S0270913984000379 [pii]
AID - 10.1002/hep.1840040117 [doi]
PST - ppublish
SO  - Hepatology. 1984 Jan-Feb;4(1):96-100. doi: 10.1002/hep.1840040117.