PMID- 669569
OWN - NLM
STAT- MEDLINE
DCOM- 19780925
LR  - 20180215
IS  - 0301-0163 (Print)
IS  - 0301-0163 (Linking)
VI  - 9
IP  - 4
DP  - 1978
TI  - Measurement of 5-androsten-3beta,17beta-diol in spermatic and peripheral venous 
      blood samples from the same human subjects by a radioimmunoassay method.
PG  - 194-200
AB  - An original method for 5-androsten-3beta,17beta-diol (A-diol) measurement using 
      an antiserum against A-diol-16-CMO-BSA is described. A-diol and testosterone (T) 
      were determined by radioimmunoassay methods in spermatic and peripheral venous 
      plasma of nine normal subjects during surgical intervention for inguinal hernia 
      repair. In spermatic venous plasma the levels of T and A-diol were, respectively, 
      25.9 +/- 13.3 and 4.8 +/- 5.1 microgram/100ml (mean +/- SD) with an A-diol/T 
      ratio of 0.19 +/- 0.15 (mean +/- SD); in peripheral plasma the levels of T and 
      A-diol were, respectively, 269 +/- 58 and 91 +/- 25 ng/100 ml (mean +/- SD) with 
      an A-diol/T ratio of 0.35 +/- 0.12 (mean +/- SD) significantly different from 
      spermatic venous plasma (p less than 0.01). From these data a mean testicular 
      A-diol secretion of about 0.70 mg/24 h can be calculated: this value corresponds 
      approximately to the 50% of the blood production rate (BPR) of this steroid. So 
      it can be assumed that a large amount of A-diol in systemic blood comes from 
      sources outside the male gonad.
FAU - Forti, G
AU  - Forti G
FAU - Calabresi, E
AU  - Calabresi E
FAU - Giannotti, P
AU  - Giannotti P
FAU - Borrelli, D
AU  - Borrelli D
FAU - Gonnelli, P
AU  - Gonnelli P
FAU - Barbieri, U
AU  - Barbieri U
FAU - Serio, M
AU  - Serio M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Switzerland
TA  - Horm Res
JT  - Hormone research
JID - 0366126
RN  - 0 (Androstenediols)
RN  - 3XMK78S47O (Testosterone)
RN  - 95PS51EMXY (Androstenediol)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Androstenediol/*blood
MH  - Androstenediols/*blood
MH  - Forearm/blood supply
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Radioimmunoassay
MH  - Spermatic Cord/*blood supply
MH  - Testosterone/blood
MH  - Veins
EDAT- 1978/01/01 00:00
MHDA- 1978/01/01 00:01
CRDT- 1978/01/01 00:00
PHST- 1978/01/01 00:00 [pubmed]
PHST- 1978/01/01 00:01 [medline]
PHST- 1978/01/01 00:00 [entrez]
AID - 10.1159/000178913 [doi]
PST - ppublish
SO  - Horm Res. 1978;9(4):194-200. doi: 10.1159/000178913.