PMID- 6698623
OWN - NLM
STAT- MEDLINE
DCOM- 19840419
LR  - 20190816
IS  - 0020-5915 (Print)
IS  - 0020-5915 (Linking)
VI  - 73
IP  - 4
DP  - 1984
TI  - Effects of compound 48/80 and formyl-methionyl-leucyl-phenylalanine on isolated 
      guinea pig airways.
PG  - 309-13
AB  - Compound 48/80 and formyl-methionyl-leucyl-phenylalanine (fMLP), but not 
      concanavalin A and dextran, contract isolated guinea pig tracheal spirals and 
      lung parenchymal strips. fMLP induced a brief histamine-independent contraction 
      of parenchymal strips. Tracheal contraction by fMLP was only observed in the 
      presence of indomethacin, suggesting the involvement of a bronchoconstrictor 
      lipoxygenase product of arachidonic acid (AA). Contractions induced by compound 
      48/80 were prolonged, were not dependent on extracellular calcium and were partly 
      inhibited in the first 10 min by mepyramine, and after this by phenidone. 
      Indomethacin enhanced contractions of trachea but inhibited contractions of 
      parenchyma. Thus, histamine only contributes to the early part of compound 
      48/80-induced airway contractions, and lipoxygenase-derived AA products 
      contribute after that. Bronchoconstrictor cyclooxygenase products may also 
      contribute to parenchymal contractions. Compound 48/80 contracts the airways in a 
      similar manner to antigen and thus may provide a useful model to examine mediator 
      release and airway smooth muscle contraction.
FAU - Burka, J F
AU  - Burka JF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Int Arch Allergy Appl Immunol
JT  - International archives of allergy and applied immunology
JID - 0404561
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - 59880-97-6 (N-Formylmethionine Leucyl-Phenylalanine)
RN  - HPE317O9TL (Pyrilamine)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Calcium/physiology
MH  - Guinea Pigs
MH  - Male
MH  - Muscle Contraction/drug effects
MH  - N-Formylmethionine Leucyl-Phenylalanine/*pharmacology
MH  - Pyrilamine/pharmacology
MH  - Trachea/*drug effects
MH  - p-Methoxy-N-methylphenethylamine/*pharmacology
EDAT- 1984/01/01 00:00
MHDA- 1984/01/01 00:01
CRDT- 1984/01/01 00:00
PHST- 1984/01/01 00:00 [pubmed]
PHST- 1984/01/01 00:01 [medline]
PHST- 1984/01/01 00:00 [entrez]
AID - 10.1159/000233490 [doi]
PST - ppublish
SO  - Int Arch Allergy Appl Immunol. 1984;73(4):309-13. doi: 10.1159/000233490.