PMID- 6699136
OWN - NLM
STAT- MEDLINE
DCOM- 19840420
LR  - 20161019
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 58
IP  - 4
DP  - 1984 Apr
TI  - Vitamin D metabolism in familial benign hypercalcemia (hypocalciuric 
      hypercalcemia) differs from that in primary hyperparathyroidism.
PG  - 744-7
AB  - We compared serum concentrations of immunoreactive PTH and plasma levels of 
      vitamin D metabolites in 11 patients with adenomatous primary hyperparathyroidism 
      and 32 individuals with the syndrome of familial benign hypercalcemia or familial 
      hypocalciuric hypercalcemia (FHH). Serum immunoreactive PTH was elevated in the 
      hyperparathyroid group but indistinguishable from control in FHH, despite 
      comparable degrees of hypercalcemia. Plasma 25-hydroxyvitamin D concentrations 
      were normal in both groups, but plasma 1,25-dihydroxyvitamin D levels in FHH were 
      significantly lower than control (P less than 0.0025) or hyperparathyroid (P less 
      than 0.01) values. FHH is pathogenetically distinct from primary 
      hyperparathyroidism and should not be thought of simply as a variant of that 
      condition.
FAU - Law, W M Jr
AU  - Law WM Jr
FAU - Bollman, S
AU  - Bollman S
FAU - Kumar, R
AU  - Kumar R
FAU - Heath, H 3rd
AU  - Heath H 3rd
LA  - eng
GR  - R01 DK025409/DK/NIDDK NIH HHS/United States
GR  - AM-19607/AM/NIADDK NIH HHS/United States
GR  - AM-25409/AM/NIADDK NIH HHS/United States
GR  - AM-27440/AM/NIADDK NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Parathyroid Hormone)
RN  - 1406-16-2 (Vitamin D)
RN  - 27YLU75U4W (Phosphorus)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Calcium/blood
MH  - Female
MH  - Humans
MH  - Hypercalcemia/*blood/genetics
MH  - Hyperparathyroidism/*blood
MH  - Male
MH  - Middle Aged
MH  - Parathyroid Hormone/blood
MH  - Phosphorus/blood
MH  - Vitamin D/*blood
EDAT- 1984/04/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1984/04/01 00:00
PHST- 1984/04/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1984/04/01 00:00 [entrez]
AID - 10.1210/jcem-58-4-744 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 1984 Apr;58(4):744-7. doi: 10.1210/jcem-58-4-744.