PMID- 6699783
OWN - NLM
STAT- MEDLINE
DCOM- 19840425
LR  - 20190511
IS  - 0022-3751 (Print)
IS  - 1469-7793 (Electronic)
IS  - 0022-3751 (Linking)
VI  - 346
DP  - 1984 Jan
TI  - Central effects of dopamine on vasopressin release in the normally hydrated and 
      water-loaded rat.
PG  - 49-59
AB  - The effect of intracerebroventricular (I.C.V.) micro-injections of dopamine on 
      vasopressin (AVP) release was investigated in normally hydrated and hydrated rats 
      anaesthetized with urethane, hormone concentrations being determined by 
      radioimmunoassay. Dopamine given in doses of less than 25 micrograms had little 
      effect on AVP concentrations already elevated as a result of anaesthesia and 
      surgery. Doses of over 25 micrograms produced a transient increase in AVP 
      concentrations followed by a fall. Both the increase and the fall were 
      statistically significant. Pimozide (400 micrograms/kg) blocked the fall in AVP 
      concentrations following dopamine. A fall was still seen after the administration 
      of haloperidol (400 micrograms/kg) but it was only significant 20 min after the 
      injection of dopamine. The changes in AVP concentration after the administration 
      of naloxone (400 micrograms/kg) were not statistically significant. In 
      water-loaded rats I.C.V. micro-injections of dopamine produced a dose-dependent 
      antidiuresis over the range 1-25 micrograms. An injection of 25 micrograms 
      dopamine in these animals produced an increase in AVP concentrations to 1.8 +/- 
      0.51 microunits/ml and a fall in urine flow which could be approximately matched 
      by an infusion of vasopressin of 15 microunits/min. The antidiuresis in response 
      to dopamine could be blocked by haloperidol. The response to dopamine in the 
      anaesthetized animals depends on a number of factors including the initial 
      activity of the neurohypophysial system.
FAU - Forsling, M L
AU  - Forsling ML
FAU - Williams, H
AU  - Williams H
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Physiol
JT  - The Journal of physiology
JID - 0266262
RN  - 059QF0KO0R (Water)
RN  - 11000-17-2 (Vasopressins)
RN  - 1HIZ4DL86F (Pimozide)
RN  - 36B82AMQ7N (Naloxone)
RN  - J6292F8L3D (Haloperidol)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Diuresis/drug effects
MH  - Dopamine/administration & dosage/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Haloperidol/pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Microinjections
MH  - Naloxone/pharmacology
MH  - Pimozide/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Vasopressins/*blood
MH  - Water
PMC - PMC1199483
EDAT- 1984/01/01 00:00
MHDA- 1984/01/01 00:01
PMCR- 1984/01/01
CRDT- 1984/01/01 00:00
PHST- 1984/01/01 00:00 [pubmed]
PHST- 1984/01/01 00:01 [medline]
PHST- 1984/01/01 00:00 [entrez]
PHST- 1984/01/01 00:00 [pmc-release]
AID - 10.1113/jphysiol.1984.sp015006 [doi]
PST - ppublish
SO  - J Physiol. 1984 Jan;346:49-59. doi: 10.1113/jphysiol.1984.sp015006.