PMID- 6702625
OWN - NLM
STAT- MEDLINE
DCOM- 19840413
LR  - 20190622
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 53
IP  - 6
DP  - 1984 Mar 1
TI  - Thallium-201 scintigraphy in complete left bundle branch block.
PG  - 764-9
AB  - Nineteen symptomatic patients with left bundle branch block (LBBB) were examined 
      by thallium-201 (TI-201) exercise scintigraphy and selective coronary 
      arteriography. All elicited significant anteroseptal perfusion defects in the 
      exercise scintigrams, but in only 4 was coronary artery disease (CAD) involving 
      the left anterior descending coronary artery present. To further elucidate the 
      effect of LBBB on septal TI-201 uptake in the absence of CAD, TI-201 scintigrams 
      combined with regional myocardial blood flow measurements using radioactive 
      microspheres were carried out in 7 dogs during right atrial and right ventricular 
      pacing (LBBB in the ECG) at similar heart rates. During right atrial pacing, 
      TI-201 uptake was homogeneous in the entire left ventricle, as were tissue flows. 
      During right ventricular pacing, TI-201 activity was reduced to 69% of maximal 
      TI-201 activity within the septum, whereas it averaged 90% in the lateral wall (p 
      less than 0.05) in 6 dogs. Correspondingly, regional myocardial blood flow was 
      lower within the septum as compared with that in the lateral wall, averaging 89 
      and 120 ml/min/100 g, respectively (p less than 0.005). In 1 dog, normal TI-201 
      distribution and tissue flows were found in both studies. Thus, symptomatic 
      patients with LBBB may elicit abnormal TI-201 exercise scintigrams, suggesting 
      anteroseptal ischemia despite normal coronary arteries. The electrical induction 
      of LBBB in dogs results, in most instances, in a comparable reduction in septal 
      TI-201 uptake associated with diminished septal blood flow. Therefore, 
      exercise-induced septal perfusion defects in the presence of LBBB do not 
      necessarily indicate CAD even in symptomatic patients, but may reflect functional 
      ischemia due to asynchronous septal contraction.
FAU - Hirzel, H O
AU  - Hirzel HO
FAU - Senn, M
AU  - Senn M
FAU - Nuesch, K
AU  - Nuesch K
FAU - Buettner, C
AU  - Buettner C
FAU - Pfeiffer, A
AU  - Pfeiffer A
FAU - Hess, O M
AU  - Hess OM
FAU - Krayenbuehl, H P
AU  - Krayenbuehl HP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 0 (Radioisotopes)
RN  - AD84R52XLF (Thallium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Bundle-Branch Block/*diagnostic imaging
MH  - Coronary Circulation
MH  - Dogs
MH  - Female
MH  - Heart/*diagnostic imaging
MH  - Hemodynamics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Radioisotopes
MH  - Radionuclide Imaging
MH  - *Thallium/metabolism
EDAT- 1984/03/01 00:00
MHDA- 1984/03/01 00:01
CRDT- 1984/03/01 00:00
PHST- 1984/03/01 00:00 [pubmed]
PHST- 1984/03/01 00:01 [medline]
PHST- 1984/03/01 00:00 [entrez]
AID - 0002-9149(84)90400-4 [pii]
AID - 10.1016/0002-9149(84)90400-4 [doi]
PST - ppublish
SO  - Am J Cardiol. 1984 Mar 1;53(6):764-9. doi: 10.1016/0002-9149(84)90400-4.