PMID- 6703733
OWN - NLM
STAT- MEDLINE
DCOM- 19840330
LR  - 20080317
IS  - 0003-987X (Print)
IS  - 0003-987X (Linking)
VI  - 120
IP  - 3
DP  - 1984 Mar
TI  - Subacute cutaneous lupus erythematosus and discoid lupus erythematosus. 
      Comparative histopathologic findings.
PG  - 332-7
AB  - Subacute cutaneous lupus erythematosus (SCLE) is a recently described distinct 
      subset of lupus erythematosus (LE) having characteristic clinical, serologic, and 
      genetic findings. This study describes the histopathologic characteristics of 
      SCLE and determines whether it could be differentiated from discoid lupus 
      erythematosus (DLE) on histopathologic grounds alone. Biopsy specimens from 33 
      patients having either SCLE or DLE, as defined by strict clinical criteria, were 
      examined without knowledge of the clinical diagnosis. Histologic discrimination 
      between SCLE and DLE was accomplished in 82%. The specimens from DLE lesions had 
      substantially more hyperkeratosis, basement membrane thickening, follicular 
      plugging, and superficial and deep inflammatory cell infiltrate, while SCLE had 
      more epidermal atrophy. The histopathologic differences between SCLE and DLE 
      further support the concept that SCLE is distinct from DLE and should be 
      considered a unique subset of LE.
FAU - Bangert, J L
AU  - Bangert JL
FAU - Freeman, R G
AU  - Freeman RG
FAU - Sontheimer, R D
AU  - Sontheimer RD
FAU - Gilliam, J N
AU  - Gilliam JN
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Arch Dermatol
JT  - Archives of dermatology
JID - 0372433
SB  - IM
MH  - Acute Disease
MH  - Basement Membrane/pathology
MH  - Diagnosis, Differential
MH  - Humans
MH  - Lupus Erythematosus, Discoid/*pathology
MH  - Lupus Erythematosus, Systemic/*pathology
EDAT- 1984/03/01 00:00
MHDA- 1984/03/01 00:01
CRDT- 1984/03/01 00:00
PHST- 1984/03/01 00:00 [pubmed]
PHST- 1984/03/01 00:01 [medline]
PHST- 1984/03/01 00:00 [entrez]
PST - ppublish
SO  - Arch Dermatol. 1984 Mar;120(3):332-7.