PMID- 6708592
OWN - NLM
STAT- MEDLINE
DCOM- 19840502
LR  - 20190516
IS  - 0025-6196 (Print)
IS  - 0025-6196 (Linking)
VI  - 59
IP  - 3
DP  - 1984 Mar
TI  - High-resolution parathyroid ultrasonography in familial benign hypercalcemia 
      (familial hypocalciuric hypercalcemia).
PG  - 153-5
AB  - Familial benign hypercalcemia, or familial hypocalciuric hypercalcemia (FHH), is 
      frequently confused with primary hyperparathyroidism, but the consistent failure 
      of subtotal parathyroidectomy to normalize serum calcium levels in FHH makes 
      accurate distinction from familial hyperparathyroidism imperative. Because 
      ultrasonography frequently demonstrates enlargement of the parathyroid glands in 
      hyperparathyroidism, we examined 14 hypercalcemic adults (who had not undergone 
      operation) from seven kindreds with FHH by using a high-resolution real-time 
      scanner. We compared our results with those from 156 patients (who had undergone 
      scanning preoperatively) with surgically confirmed hyperparathyroidism. 
      Enlargement of the parathyroid glands was detected ultrasonographically in 137 of 
      156 (88%) of the total group of patients with hyperparathyroidism and in 17 of 24 
      patients (71%) with hyperparathyroidism who had hypercalcemia (serum calcium, 
      10.6 to 11.0 mg/dl) comparable to that of the FHH group (mean value, 10.7 mg/dl). 
      In contrast, the single possible parathyroid lesion seen in the FHH group was 
      substantially smaller (4 mm) than the smallest (7 mm, 75 mg) abnormal gland 
      reliably detected by ultrasonography in the group with hyperparathyroidism and 
      was conceivably normal in size. Patients with FHH have a dramatic absence of 
      ultrasonographic parathyroid enlargement. High-resolution parathyroid 
      ultrasonography may be of ancillary diagnostic benefit in patients with familial 
      hypercalcemia.
FAU - Law, W M Jr
AU  - Law WM Jr
FAU - James, E M
AU  - James EM
FAU - Charboneau, J W
AU  - Charboneau JW
FAU - Purnell, D C
AU  - Purnell DC
FAU - Heath, H 3rd
AU  - Heath H 3rd
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Mayo Clin Proc
JT  - Mayo Clinic proceedings
JID - 0405543
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Calcium/*urine
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Hypercalcemia/*genetics
MH  - Hyperparathyroidism/diagnosis
MH  - Hypertrophy/diagnosis
MH  - Male
MH  - Middle Aged
MH  - Parathyroid Glands/*pathology/surgery
MH  - *Ultrasonography
EDAT- 1984/03/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1984/03/01 00:00
PHST- 1984/03/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1984/03/01 00:00 [entrez]
AID - S0025-6196(12)60766-6 [pii]
AID - 10.1016/s0025-6196(12)60766-6 [doi]
PST - ppublish
SO  - Mayo Clin Proc. 1984 Mar;59(3):153-5. doi: 10.1016/s0025-6196(12)60766-6.