PMID- 6714309
OWN - NLM
STAT- MEDLINE
DCOM- 19840605
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 98
IP  - 2
DP  - 1984 Feb 17
TI  - TAG antagonises the central cardiovascular effects of taurine.
PG  - 269-73
AB  - The taurine antagonist TAG was examined for its blocking activity towards the 
      central cardiovascular effects of taurine and muscimol. Intracerebroventricular 
      (i.c.v.) injections of taurine (1-1000 micrograms/kg) and muscimol (0.1-3 
      micrograms/kg) in the anesthetised cat led to hypotension and bradycardia. 
      Pretreatment with TAG (1 mg/kg i.c.v.) antagonised the blood pressure effects of 
      taurine. The selectivity of this antagonism is discussed since TAG also shifted 
      to the right the blood pressure dose-response curve obtained with muscimol.
FAU - Bousquet, P
AU  - Bousquet P
FAU - Feldman, J
AU  - Feldman J
FAU - Bloch, R
AU  - Bloch R
FAU - Schwartz, J
AU  - Schwartz J
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Benzothiadiazines)
RN  - 1EQV5MLY3D (Taurine)
RN  - 2763-96-4 (Muscimol)
RN  - 80938-51-8 (6-aminomethyl-3-methyl-4H-1,2,4-benzothiadiazine 1,1-dioxide)
SB  - IM
MH  - Animals
MH  - Benzothiadiazines/*pharmacology
MH  - Blood Pressure/*drug effects
MH  - Brain/physiology
MH  - Cats
MH  - Dose-Response Relationship, Drug
MH  - Heart Rate/*drug effects
MH  - Muscimol/antagonists & inhibitors
MH  - Taurine/*antagonists & inhibitors
EDAT- 1984/02/17 00:00
MHDA- 1984/02/17 00:01
CRDT- 1984/02/17 00:00
PHST- 1984/02/17 00:00 [pubmed]
PHST- 1984/02/17 00:01 [medline]
PHST- 1984/02/17 00:00 [entrez]
AID - 0014-2999(84)90600-9 [pii]
AID - 10.1016/0014-2999(84)90600-9 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1984 Feb 17;98(2):269-73. doi: 10.1016/0014-2999(84)90600-9.