PMID- 6715275
OWN - NLM
STAT- MEDLINE
DCOM- 19840614
LR  - 20190511
IS  - 0021-8812 (Print)
IS  - 0021-8812 (Linking)
VI  - 58
IP  - 3
DP  - 1984 Mar
TI  - Antibiotic resistance of fecal coliforms from swine fed subtherapeutic and 
      therapeutic levels of chlortetracycline.
PG  - 666-74
AB  - The effect of feeding subtherapeutic (27.5 micrograms/g of diet for 85 d) and 
      therapeutic (220 micrograms/g of diet for 14 d, followed by an antibiotic-free 
      diet for 71 d) levels of chlortetracycline (CTC) on the antibiotic resistance of 
      fecal coliforms of pigs from two herds (36 pigs/herd) with different histories of 
      antibiotic exposure when housed in a newly constructed confinement facility was 
      determined. The CTC-resistant coliforms were higher (65 vs 51%) for antibiotic 
      (AB) pigs than for nonantibiotic (NAB) pigs after they had been fed an 
      antibiotic-free diet for 21 d. Percentages of isolates resistant to ampicillin, 
      kanamycin, neomycin and tetracycline and multiple antibiotic resistance were 
      greater (P less than .05) in AB pigs after 21 d. Feeding subtherapeutic CTC 
      resulted in a linear increase in CTC-resistant coliforms with time on experiment 
      (P less than .03, NAB; P less than .06, AB). The CTC-resistant coliforms 
      increased during the 14 d that therapeutic CTC was fed, then they decreased 
      during the 71 d that the antibiotic-free diet was fed, resulting in a quadratic 
      response with time (P less than .03, AB). Feeding subtherapeutic CTC resulted in 
      a greater increase in CTC-resistant coliforms in AB (47%) than in NAB (23%) pigs. 
      The CTC-resistant coliforms decreased after the therapeutic group had been 
      returned to the antibiotic-free diet (P less than .05, NAB). Feeding CTC caused 
      greater changes in the precentages of isolates from NAB pigs that were resistant 
      to selected antibiotics and in multiple antibiotic resistance than in isolates 
      from AB pigs.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Langlois, B E
AU  - Langlois BE
FAU - Dawson, K A
AU  - Dawson KA
FAU - Stahly, T S
AU  - Stahly TS
FAU - Cromwell, G L
AU  - Cromwell GL
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Anim Sci
JT  - Journal of animal science
JID - 8003002
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Food Additives)
RN  - WCK1KIQ23Q (Chlortetracycline)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/*pharmacology
MH  - Chlortetracycline/*administration & dosage/pharmacology
MH  - Drug Resistance, Microbial
MH  - Enterobacteriaceae/*drug effects
MH  - Feces/microbiology
MH  - Food Additives
MH  - Swine/*microbiology
EDAT- 1984/03/01 00:00
MHDA- 1984/03/01 00:01
CRDT- 1984/03/01 00:00
PHST- 1984/03/01 00:00 [pubmed]
PHST- 1984/03/01 00:01 [medline]
PHST- 1984/03/01 00:00 [entrez]
AID - 10.2527/jas1984.583666x [doi]
PST - ppublish
SO  - J Anim Sci. 1984 Mar;58(3):666-74. doi: 10.2527/jas1984.583666x.