PMID- 6715795
OWN - NLM
STAT- MEDLINE
DCOM- 19840611
LR  - 20181113
IS  - 0391-4097 (Print)
IS  - 0391-4097 (Linking)
VI  - 7
IP  - 1
DP  - 1984 Feb
TI  - Circulating immunoglobulin E (IgE) antibodies to L-thyroxine in a euthyroid 
      patient with multinodular goiter and allergic rhinitis.
PG  - 47-50
AB  - A 30-yr-old woman with allergic rhinitis and multinodular goiter developed atopic 
      manifestations on different desiccated thyroid extract treatment. Urticaria was 
      observed when the patient was on L-T4 treatment; no atopy was experienced during 
      L-T3 regimen. Serum total immunoglobulin E (IgE) concentration was 390 +/- 
      7kU/liter (mean +/- SD) prior to any treatment and rose to 850 +/- 7.5 kU/liter 
      when the patient developed urticaria, but declined to baseline figures while she 
      was on L-T3. Intracutaneous testing was positive for desiccated pork thyroid 
      powder, L-T4 and D-T4, but negative for L-T3, DIT and L-tyrosine. 
      Immunoradioligand analyses of mixtures of patient's serum or precipitated 
      immunoglobulin fraction and of 125I-T4 or of 125I-T3 revealed binding of 
      radiolabeled thyroxine to the patient's serum IgE, in turn bound to 
      anti-human-IgE serum covalently coupled to paper discs. This binding was 
      completely inhibited by the preincubation of immunoglobulin fraction with excess 
      unlabeled L-T4 and D-T4, but not with excess nonradioactive L-T3, thus proving 
      the specificity of the binding. Preadsorption experiments performed with 
      desiccated pork thyroid powder solution mixed with the patient's immunoglobulin 
      fraction suggested binding of some unknown component(s) of desiccated thyroid 
      which was apparently not thyroglobulin. This study provides evidence of IgE 
      antibodies to L-T4 cross reacting with D-T4 and capable of binding 125I-T4 in 
      serum. It also suggests a model for the detection of circulating IgE antibodies 
      to thyroid hormones.
FAU - Benvenga, S
AU  - Benvenga S
FAU - Trimarchi, F
AU  - Trimarchi F
FAU - Barbera, C
AU  - Barbera C
FAU - Costante, G
AU  - Costante G
FAU - Morabito, S
AU  - Morabito S
FAU - Barberio, G
AU  - Barberio G
FAU - Consolo, F
AU  - Consolo F
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
RN  - 0 (Thyroid (USP))
RN  - 37341-29-0 (Immunoglobulin E)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Adult
MH  - Female
MH  - Goiter, Nodular/complications/*immunology
MH  - Humans
MH  - Immunoglobulin E/*isolation & purification
MH  - Rhinitis, Allergic, Seasonal/complications/*immunology
MH  - Thyroid (USP)/immunology
MH  - Thyroxine/*immunology
EDAT- 1984/02/01 00:00
MHDA- 1984/02/01 00:01
CRDT- 1984/02/01 00:00
PHST- 1984/02/01 00:00 [pubmed]
PHST- 1984/02/01 00:01 [medline]
PHST- 1984/02/01 00:00 [entrez]
AID - 10.1007/BF03348375 [doi]
PST - ppublish
SO  - J Endocrinol Invest. 1984 Feb;7(1):47-50. doi: 10.1007/BF03348375.