PMID- 6717539
OWN - NLM
STAT- MEDLINE
DCOM- 19840620
LR  - 20161123
IS  - 0028-4793 (Print)
IS  - 0028-4793 (Linking)
VI  - 310
IP  - 23
DP  - 1984 Jun 7
TI  - Cognitive function and age at repair of transposition of the great arteries in 
      children.
PG  - 1495-9
AB  - To assess the effect of the duration of chronic hypoxemia on cognitive function, 
      we studied 38 children with d-transposition of the great arteries and an intact 
      ventricular septum who underwent corrective surgery at six months to six years of 
      age (median, 1.6 years). Tests included the Wechsler Preschool and Primary Scale 
      of Intelligence (WPPSI) in 33 children and the visual-association and 
      auditory-association subtests of the Illinois Test of Psycholinguistic Abilities 
      in 38 and 37 children, respectively. When controlled for social index, age at 
      repair was inversely associated with the WPPSI intelligence-quotient score (P 
      less than 0.01), the visual-association subtest score (P less than 0.01), and the 
      auditory-association subtest score (P less than 0.1). In contrast, age at repair 
      correlated poorly with cognitive function in children with ventricular septal 
      defect, an acyanotic congenital heart defect. These data suggest that postponing 
      repair of a cyanotic congenital heart disease, such as transposition of the great 
      arteries, is associated with progressive impairment of cognitive function.
FAU - Newburger, J W
AU  - Newburger JW
FAU - Silbert, A R
AU  - Silbert AR
FAU - Buckley, L P
AU  - Buckley LP
FAU - Fyler, D C
AU  - Fyler DC
LA  - eng
GR  - HL 05855/HL/NHLBI NIH HHS/United States
GR  - HL 10436/HL/NHLBI NIH HHS/United States
GR  - HL 32357/HL/NHLBI NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - N Engl J Med
JT  - The New England journal of medicine
JID - 0255562
SB  - IM
MH  - Age Factors
MH  - Auditory Perception
MH  - Child, Preschool
MH  - *Cognition
MH  - Female
MH  - Humans
MH  - Hypoxia/psychology
MH  - Infant
MH  - Intelligence Tests
MH  - Male
MH  - Transposition of Great Vessels/physiopathology/psychology/*surgery
MH  - Visual Perception
EDAT- 1984/06/07 00:00
MHDA- 1984/06/07 00:01
CRDT- 1984/06/07 00:00
PHST- 1984/06/07 00:00 [pubmed]
PHST- 1984/06/07 00:01 [medline]
PHST- 1984/06/07 00:00 [entrez]
AID - 10.1056/NEJM198406073102303 [doi]
PST - ppublish
SO  - N Engl J Med. 1984 Jun 7;310(23):1495-9. doi: 10.1056/NEJM198406073102303.