PMID- 6717754
OWN - NLM
STAT- MEDLINE
DCOM- 19840607
LR  - 20190726
IS  - 0028-3908 (Print)
IS  - 0028-3908 (Linking)
VI  - 23
IP  - 1
DP  - 1984 Jan
TI  - Comparison of the antinociceptive effects of intracerebroventricular injection of 
      kyotorphin, cyclo (N-methyl-Tyr-Arg) and Met-enkephalin in mice.
PG  - 7-12
AB  - Intracerebroventricular (i.c.v.) administration of kyotorphin 
      (L-Tyrosine-L-Arginine) or Metenkephalin (Met-ENK) to conscious mice resulted in 
      a dose-dependent antinociceptive effect as measured by three pain tests. 
      Cyclo(N-methyl-L-Tyrosine-L-Arginine) (cyclo NMTA), an analogue of kyotorphin, 
      increased the reaction time in the tail-pressure and tail-flick tests. Both 
      dipeptides also decreased writhing induced by acetic acid. However, the 
      antinociceptive activity of cyclo NMTA was substantially greater than that of 
      kyotorphin or Met-enkephalin. At the maximum effective dose of 62.7 nmol/mouse, 
      this cyclic dipeptide produced a more long-lasting antinociceptive effect than 
      did kyotorphin or Met-enkephalin. Antinociception induced by cyclo NMTA or 
      kyotorphin was significantly reversed by pretreatment with naloxone (2 or 8 
      mg/kg, i.p.), though naloxone was not as effective an antagonist of the 
      antinociceptive action of these peptides as it was against Met-enkephalin. The 
      results indicate that the antinociceptive effect induced by cyclo NMTA may in 
      part involve the endogenous opioid system in mice.
FAU - Sakurada, T
AU  - Sakurada T
FAU - Sakurada, S
AU  - Sakurada S
FAU - Watanabe, S
AU  - Watanabe S
FAU - Kawamura, S
AU  - Kawamura S
FAU - Sato, T
AU  - Sato T
FAU - Kisara, K
AU  - Kisara K
FAU - Akutsu, Y
AU  - Akutsu Y
FAU - Sasaki, Y
AU  - Sasaki Y
FAU - Suzuki, K
AU  - Suzuki K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Analgesics)
RN  - 0 (Endorphins)
RN  - 0 (Peptides, Cyclic)
RN  - 02N30CW3X0 (kyotorphin)
RN  - 36B82AMQ7N (Naloxone)
RN  - 58569-55-4 (Enkephalin, Methionine)
RN  - 83481-39-4 (cyclo(N-methyltyrosylarginyl))
SB  - IM
MH  - *Analgesia
MH  - *Analgesics
MH  - Animals
MH  - Endorphins/administration & dosage/*pharmacology
MH  - Enkephalin, Methionine/administration & dosage/*pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Mice
MH  - Naloxone/pharmacology
MH  - Nociceptors/drug effects
MH  - Peptides, Cyclic/administration & dosage/*pharmacology
EDAT- 1984/01/01 00:00
MHDA- 1984/01/01 00:01
CRDT- 1984/01/01 00:00
PHST- 1984/01/01 00:00 [pubmed]
PHST- 1984/01/01 00:01 [medline]
PHST- 1984/01/01 00:00 [entrez]
AID - 10.1016/0028-3908(84)90209-0 [doi]
PST - ppublish
SO  - Neuropharmacology. 1984 Jan;23(1):7-12. doi: 10.1016/0028-3908(84)90209-0.