PMID- 6727776
OWN - NLM
STAT- MEDLINE
DCOM- 19840712
LR  - 20190904
IS  - 0098-1532 (Print)
IS  - 0098-1532 (Linking)
VI  - 12
IP  - 3
DP  - 1984
TI  - Anaphylactic reaction to cytarabine: in vitro evidence that the response is 
      immunoglobulin E mediated.
PG  - 201-3
AB  - A 48-year-old female developed significant bronchospasm on two occasions after 
      being treated with cytarabine (Ara-C) by the intraperitoneal route. In this 
      report we present the first in vitro evidence that such a reaction to cytarabine 
      can be associated with the release of histamine and therefore might be 
      immunoglobulin E (IgE) mediated. In addition, this report emphasizes the fact 
      that, while uncommon, severe allergic reactions to this useful chemotherapeutic 
      agent do occur and must be considered in the differential diagnosis of 
      anaphylaxis and related symptoms in patients receiving this drug.
FAU - Markman, M
AU  - Markman M
FAU - Howell, S B
AU  - Howell SB
FAU - King, M
AU  - King M
FAU - Pfeifle, C
AU  - Pfeifle C
FAU - Wasserman, S I
AU  - Wasserman SI
LA  - eng
GR  - AI 00431/AI/NIAID NIH HHS/United States
GR  - AI 17268/AI/NIAID NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Med Pediatr Oncol
JT  - Medical and pediatric oncology
JID - 7506654
RN  - 04079A1RDZ (Cytarabine)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Anaphylaxis/*chemically induced/immunology
MH  - Cytarabine/administration & dosage/*adverse effects/pharmacology
MH  - Female
MH  - Histamine/blood
MH  - Humans
MH  - Immunoglobulin E/*immunology
MH  - Injections, Intraperitoneal
MH  - Middle Aged
EDAT- 1984/01/01 00:00
MHDA- 1984/01/01 00:01
CRDT- 1984/01/01 00:00
PHST- 1984/01/01 00:00 [pubmed]
PHST- 1984/01/01 00:01 [medline]
PHST- 1984/01/01 00:00 [entrez]
AID - 10.1002/mpo.2950120311 [doi]
PST - ppublish
SO  - Med Pediatr Oncol. 1984;12(3):201-3. doi: 10.1002/mpo.2950120311.