PMID- 6730783
OWN - NLM
STAT- MEDLINE
DCOM- 19840709
LR  - 20131121
IS  - 0176-6724 (Print)
IS  - 0176-6724 (Linking)
VI  - 256
IP  - 3
DP  - 1984 Mar
TI  - Studies on the activity of Obioactin with acetylspiramycin on mice infected with 
      Toxoplasma gondii.
PG  - 367-80
AB  - In acutely infected mice, acetylspiramycin (ASPM) administered in combination 
      with Obioactin , or sulfamethoxypyrazine ( SMPZ ), prevented Toxoplasma organisms 
      from encysting in the brain and heart tissues. When administered alone, ASPM 
      prevented these organisms from encysting in the heart but not in the brain. All 
      the regimens used failed to reduce the bulk of parasites in the brain and heart 
      tissues of chronically infected mice. Treatment with an ASPM- Obioactin 
      combination, however, brought about the most remarkable reduction, or 52.4%, of 
      the cyst count in the brain of all the methods of treatment applied. Light and 
      electron microscopy of the mice with chronic Toxoplasma infection revealed no 
      changes in the brain or heart tissue of the ASPM- Obioactin treated mice and 
      degenerative changes in the cyst wall and bradyzoites and a remarkable increase 
      of microglias with cysts in the brain in some of these mice.
FAU - Suzuki, N
AU  - Suzuki N
FAU - Espinas, F M
AU  - Espinas FM
FAU - Sakurai, H
AU  - Sakurai H
FAU - Saito, A
AU  - Saito A
FAU - Sasaki, H
AU  - Sasaki H
FAU - Kato, G
AU  - Kato G
FAU - Manba, K
AU  - Manba K
FAU - Taniguchi, K
AU  - Taniguchi K
FAU - Mochizuki, K
AU  - Mochizuki K
FAU - Osaki, H
AU  - Osaki H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Zentralbl Bakteriol Mikrobiol Hyg A
JT  - Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical 
      microbiology, infectious diseases, virology, parasitology
JID - 8403032
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Antiprotozoal Agents)
RN  - 0 (Immunoglobulins)
RN  - 0 (Leucomycins)
RN  - 0 (obioactin)
RN  - 05298J5WMU (acetylspiramycin)
RN  - 8025-81-8 (Spiramycin)
RN  - T034E4NS2Z (Sulfamethoxypyridazine)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/*therapeutic use
MH  - Anti-Infective Agents/pharmacology/*therapeutic use
MH  - Antiprotozoal Agents/pharmacology/*therapeutic use
MH  - Brain/parasitology
MH  - Cell Division/drug effects
MH  - Drug Therapy, Combination
MH  - Heart/parasitology
MH  - *Immunoglobulins
MH  - Leucomycins/therapeutic use
MH  - Mice
MH  - Mice, Inbred Strains
MH  - *Spiramycin/*analogs & derivatives
MH  - Sulfamethoxypyridazine/therapeutic use
MH  - Toxoplasma/cytology/drug effects
MH  - Toxoplasmosis/*drug therapy/parasitology
EDAT- 1984/03/01 00:00
MHDA- 1984/03/01 00:01
CRDT- 1984/03/01 00:00
PHST- 1984/03/01 00:00 [pubmed]
PHST- 1984/03/01 00:01 [medline]
PHST- 1984/03/01 00:00 [entrez]
PST - ppublish
SO  - Zentralbl Bakteriol Mikrobiol Hyg A. 1984 Mar;256(3):367-80.