PMID- 6740557
OWN - NLM
STAT- MEDLINE
DCOM- 19840813
LR  - 20041117
IS  - 0340-6245 (Print)
IS  - 0340-6245 (Linking)
VI  - 51
IP  - 2
DP  - 1984 Apr 30
TI  - High and low affinity heparin compared with unfractionated heparin as 
      antithrombotic drugs.
PG  - 254-6
AB  - A preparation of heparin was separated by affinity chromatography into two 
      fractions: one of high ( HAH ) and the other of low (LAH) affinity to 
      antithrombin III. These two fractions were compared with unfractionated heparin ( 
      UFH ) by in vitro assay and their ability to impair experimental stasis 
      thrombosis was also examined. Although the in vitro activity of HAH was double 
      that of UFH , HAH was less effective than UFH as an antithrombotic drug; LAH was 
      virtually inactive, both in vitro and in vivo. A mixture of 30 micrograms/kg of 
      HAH and 50 micrograms/kg of LAH was as effective in preventing thrombosis as 80 
      micrograms/kg of UFH , and was more effective than 40 micrograms/kg of HAH alone, 
      demonstrating that LAH potentiates the action of HAH in vivo.
FAU - Merton, R E
AU  - Merton RE
FAU - Thomas, D P
AU  - Thomas DP
FAU - Havercroft, S J
AU  - Havercroft SJ
FAU - Barrowcliffe, T W
AU  - Barrowcliffe TW
FAU - Lindahl, U
AU  - Lindahl U
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Thromb Haemost
JT  - Thrombosis and haemostasis
JID - 7608063
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Animals
MH  - Blood Coagulation/*drug effects
MH  - Chromatography, Affinity/*methods
MH  - Dose-Response Relationship, Drug
MH  - Heparin/*analysis/pharmacology
MH  - Humans
MH  - Partial Thromboplastin Time
MH  - Rabbits
MH  - Thrombosis/prevention & control
EDAT- 1984/04/30 00:00
MHDA- 1984/04/30 00:01
CRDT- 1984/04/30 00:00
PHST- 1984/04/30 00:00 [pubmed]
PHST- 1984/04/30 00:01 [medline]
PHST- 1984/04/30 00:00 [entrez]
PST - ppublish
SO  - Thromb Haemost. 1984 Apr 30;51(2):254-6.