PMID- 6748855
OWN - NLM
STAT- MEDLINE
DCOM- 19840907
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 35
IP  - 4
DP  - 1984 Jul 23
TI  - The effects of ouabain in the medullary site of the hypotensive action of 
      clonidine.
PG  - 373-80
AB  - Blood pressure was studied in pentobarbital anesthetized rats and cats after 
      central administration of ouabain. Intracerebroventricular (i.c.v.) injections 
      caused a classical biphasic effect, a short lasting hypotension followed by a 
      hypertensive phase. When injected directly into the nucleus reticularis lateralis 
      region (NRL), ouabain (0.01-2 micrograms/kg) caused a dose-dependent pressor 
      effect. In the same region, kryptofix 221, a sodium complexing agent, produced a 
      fall in blood pressure. Moreover, central administration of ouabain prevented the 
      hypotensive effect of i.v. clonidine whereas the central hypotensive effect of 
      muscimol was not affected. It is concluded that sodium movements play an 
      important role in the blood pressure regulation within the NRL region. We also 
      report here that ouabain antagonizes the hypotensive effect of clonidine 
      suggesting that sodium movement might be the essential link of this action.
FAU - Bousquet, P
AU  - Bousquet P
FAU - Feldman, J
AU  - Feldman J
FAU - Schwartz, J
AU  - Schwartz J
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Bridged Bicyclo Compounds)
RN  - 0 (Bridged Bicyclo Compounds, Heterocyclic)
RN  - 0 (Chelating Agents)
RN  - 23978-09-8 (cryptating agent 222)
RN  - 5ACL011P69 (Ouabain)
RN  - MN3L5RMN02 (Clonidine)
SB  - IM
MH  - Animals
MH  - Blood Pressure/*drug effects
MH  - Bridged Bicyclo Compounds/pharmacology
MH  - *Bridged Bicyclo Compounds, Heterocyclic
MH  - Cats
MH  - Chelating Agents/pharmacology
MH  - Clonidine/administration & dosage/*pharmacology
MH  - Hypotension/physiopathology
MH  - Injections, Intraventricular
MH  - Medulla Oblongata/*physiology/physiopathology
MH  - Ouabain/*pharmacology
MH  - Rats
EDAT- 1984/07/23 00:00
MHDA- 1984/07/23 00:01
CRDT- 1984/07/23 00:00
PHST- 1984/07/23 00:00 [pubmed]
PHST- 1984/07/23 00:01 [medline]
PHST- 1984/07/23 00:00 [entrez]
AID - 0024-3205(84)90647-7 [pii]
AID - 10.1016/0024-3205(84)90647-7 [doi]
PST - ppublish
SO  - Life Sci. 1984 Jul 23;35(4):373-80. doi: 10.1016/0024-3205(84)90647-7.