PMID- 6761489
OWN - NLM
STAT- MEDLINE
DCOM- 19830407
LR  - 20190725
IS  - 0085-2538 (Print)
IS  - 0085-2538 (Linking)
VI  - 22
IP  - 6
DP  - 1982 Dec
TI  - An analysis of the United States renal transplant patient population and organ 
      survival characteristics: 1977 to 1980.
PG  - 685-92
AB  - This study examines the relationship between renal transplant organ survival and 
      the extent of HLA (human leukocyte antigen) A and B loci antigen matching. 
      Combined dialysis and transplant records for patients in the End Stage Renal 
      Disease Medical Information System (ESRD MIS), 1977 to 1980, were analyzed to 
      examine transplant organ survival characteristics and changes in demographic 
      pattern and donor types compared to previously reported studies of the United 
      States transplant patients. Actuarial survival curves for high match (3 or 4 HLA 
      A and B loci antigen matches) versus low match (0, 1, or 2 HLA A and B loci 
      antigen matches) groups were analyzed for their relative difference and its 
      statistical significance. In addition, this relationship was analyzed with 
      controls for age, sex, race, mixed lymphocyte culture (MLC), crossmatch, and 
      prior time on dialysis. For both cadaver and living related donor transplants, 
      statistically significant differences were found between the survival curves of 
      high and low match groups. Comparing low match and high match groups, there were 
      differences in 1-year organ survival of 4.8 and 11.3%, respectively, for cadaver 
      and living related donor transplants. MLC negative and crossmatch positive status 
      appear to improve transplant organ survival beyond the effects of HLA matching. 
      The study also designates several methodological problems inherent in transplant 
      organ survival studies including: whether or not to include patient deaths as 
      therapeutic failures, and whether or not to analyze transplant organ survival at 
      one point in time or to compare overall survival curves for the entire study 
      period.
FAU - Rosansky, S J
AU  - Rosansky SJ
FAU - Sugimoto, T
AU  - Sugimoto T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Kidney Int
JT  - Kidney international
JID - 0323470
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - Actuarial Analysis
MH  - Adolescent
MH  - Adult
MH  - Cadaver
MH  - Child
MH  - Female
MH  - HLA Antigens
MH  - HLA-A Antigens
MH  - HLA-B Antigens
MH  - *Histocompatibility Testing
MH  - Humans
MH  - *Kidney Transplantation
MH  - Male
MH  - Middle Aged
MH  - Registries
MH  - Tissue Donors
MH  - *Tissue Survival
MH  - United States
EDAT- 1982/12/01 00:00
MHDA- 1982/12/01 00:01
CRDT- 1982/12/01 00:00
PHST- 1982/12/01 00:00 [pubmed]
PHST- 1982/12/01 00:01 [medline]
PHST- 1982/12/01 00:00 [entrez]
AID - S0085-2538(15)32863-5 [pii]
AID - 10.1038/ki.1982.230 [doi]
PST - ppublish
SO  - Kidney Int. 1982 Dec;22(6):685-92. doi: 10.1038/ki.1982.230.