PMID- 6768637
OWN - NLM
STAT- MEDLINE
DCOM- 19800712
LR  - 20131121
IS  - 0016-5085 (Print)
IS  - 0016-5085 (Linking)
VI  - 78
IP  - 6
DP  - 1980 Jun
TI  - Absorption of short-chain fatty acids by the colon.
PG  - 1500-7
AB  - Short-chain fatty acids (SCFAs) constitute the major solute fraction of normal 
      stool water and are responsible for the diarrhea associated with carbohydrate 
      (CHO) malabsorption. Although SCFA absorption from the human small bowel has been 
      reported previously, the fate of SCFAs in the colon--their major site of 
      production--was investigated in the present study. The colon of normal volunteers 
      was perfused with neutral, isotonic solutions containing SCFA, 0-90 mM. 
      Propionate was studied in detail with limited observations on acetate and 
      n-butyrate. SCFA absorption was concentration-dependent; back diffusion of 
      metabolic products, ketone bodies, was quantitatively insignificant. The 
      transport process was accompanied by increased Na, K, and water absorption, by 
      luminal alkalinization due to bicarbonate accumulation, and by a fall in lumen 
      PCO2. The results are consistent with the existence of two mechanisms for colonic 
      SCFA absorption: first, nonionic diffusion of protonated SCFA involving 
      consumption of luminal CO2; this process accounts for about 60% of total SCFA 
      absorption; and second, cellular uptake by ionic diffusion of the Na or K salt of 
      the SCFA.
FAU - Ruppin, H
AU  - Ruppin H
FAU - Bar-Meir, S
AU  - Bar-Meir S
FAU - Soergel, K H
AU  - Soergel KH
FAU - Wood, C M
AU  - Wood CM
FAU - Schmitt, M G Jr
AU  - Schmitt MG Jr
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Gastroenterology
JT  - Gastroenterology
JID - 0374630
RN  - 0 (Chlorides)
RN  - 0 (Fatty Acids)
RN  - 0 (Ketone Bodies)
RN  - 142M471B3J (Carbon Dioxide)
RN  - 7YNJ3PO35Z (Hydrogen)
RN  - 9NEZ333N27 (Sodium)
RN  - RWP5GA015D (Potassium)
SB  - IM
MH  - Adult
MH  - Biological Transport
MH  - Carbon Dioxide/analysis
MH  - Chlorides/metabolism
MH  - Colon/*metabolism
MH  - Dye Dilution Technique
MH  - Fatty Acids/*metabolism
MH  - Female
MH  - Humans
MH  - Hydrogen/analysis
MH  - *Intestinal Absorption
MH  - Ketone Bodies/analysis
MH  - Male
MH  - Perfusion
MH  - Potassium/metabolism
MH  - Sodium/metabolism
EDAT- 1980/06/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1980/06/01 00:00
PHST- 1980/06/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1980/06/01 00:00 [entrez]
AID - S0016508580001114 [pii]
PST - ppublish
SO  - Gastroenterology. 1980 Jun;78(6):1500-7.