PMID- 6794896
OWN - NLM
STAT- MEDLINE
DCOM- 19820128
LR  - 20190720
IS  - 0008-4166 (Print)
IS  - 0008-4166 (Linking)
VI  - 27
IP  - 8
DP  - 1981 Aug
TI  - Effect of chemical and pharmacological agents on the secretory activity induced 
      by Escherichia coli heat-stable enterotoxin.
PG  - 754-8
AB  - The effect of aspirin (ASP), chlorpromazine (CPZ), diphenoxylate (DP), ethylene 
      glycol tetraacetate (EGTA), hydrocortisone (HC), loperamide (LPA), 
      methylprednisolone (MP), phenotolamine mesylate (PTM), propranolol (PR), and 
      trifluoperazine (TPZ) on the secretory activity induced by Escherichia coli 
      heat-stable (ST) enterotoxin in infant mice was studied. LPA and DP, which are 
      used therapeutically for diarrhea, did not inhibit the effect of ST enterotoxin; 
      MP and HC, known inhibitors of cholera enterotoxin, and two adrenergic agents (PR 
      and PTM) had no effect on ST-induced secretory activity. TPZ, EGTA, ASP, and CPZ 
      caused a significant (P less than 0.05) decrease in the secretory activity 
      induced by ST enterotoxin, CPZ, EGTA, and TPZ inhibited secretory activity 
      induced by 8-bromoguanosine 3'5'-cyclic monophosphoric acid (8-BrcGMP), a cGMP 
      analog.
FAU - Knoop, F C
AU  - Knoop FC
FAU - Abbey, D M
AU  - Abbey DM
LA  - eng
GR  - S07RR05390/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Canada
TA  - Can J Microbiol
JT  - Canadian journal of microbiology
JID - 0372707
RN  - 0 (Enterotoxins)
RN  - 214IZI85K3 (Trifluoperazine)
RN  - 526U7A2651 (Egtazic Acid)
RN  - 6X9OC3H4II (Loperamide)
RN  - 73312P173G (Diphenoxylate)
RN  - 9Y8NXQ24VQ (Propranolol)
RN  - R16CO5Y76E (Aspirin)
RN  - U42B7VYA4P (Chlorpromazine)
RN  - WI4X0X7BPJ (Hydrocortisone)
RN  - X4W7ZR7023 (Methylprednisolone)
RN  - Z468598HBV (Phentolamine)
SB  - IM
MH  - Animals
MH  - Aspirin/pharmacology
MH  - Chlorpromazine/pharmacology
MH  - Diphenoxylate/pharmacology
MH  - Egtazic Acid/pharmacology
MH  - Enterotoxins/*pharmacology
MH  - Escherichia coli/*analysis
MH  - Hydrocortisone/pharmacology
MH  - Intestinal Mucosa/*metabolism
MH  - Loperamide/pharmacology
MH  - Methylprednisolone/pharmacology
MH  - Mice
MH  - Phentolamine/pharmacology
MH  - Propranolol/pharmacology
MH  - Trifluoperazine/pharmacology
EDAT- 1981/08/01 00:00
MHDA- 1981/08/01 00:01
CRDT- 1981/08/01 00:00
PHST- 1981/08/01 00:00 [pubmed]
PHST- 1981/08/01 00:01 [medline]
PHST- 1981/08/01 00:00 [entrez]
AID - 10.1139/m81-117 [doi]
PST - ppublish
SO  - Can J Microbiol. 1981 Aug;27(8):754-8. doi: 10.1139/m81-117.