PMID- 6794904
OWN - NLM
STAT- MEDLINE
DCOM- 19820120
LR  - 20190720
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 11
IP  - 4
DP  - 1981 Feb
TI  - Aminoguanidine reversal of the inhibitory effects of ornithine analogs on the in 
      vitro clonogenic survival of the R3327AT prostate-derived tumor.
PG  - 323-30
AB  - In in vitro studies with the Copenhagen rat prostate-derived tumor cell lines, 
      the activity of ornithine decarboxylase (ODC) of these lines were as sensitive to 
      inhibition by alpha-difluoromethylornithine (alpha-DFMO) as normal prostatic 
      tissue. The in vitro growth of the tumor in calf serum was inhibited by ODC 
      inhibitors alpha-methylornithine and alpha-difluoromethylornithine. This 
      inhibition was partially reversed by the diamine oxidase inhibitor 
      aminoguanidine. Further, alpha-DFMO was not inhibitory to the growth of these 
      cells in sera which lacked diamine oxidase activity, but was inhibitory when 
      diamine oxidase was added.
FAU - Heston, W D
AU  - Heston WD
FAU - Lazan, D W
AU  - Lazan DW
FAU - Fair, W R
AU  - Fair WR
LA  - eng
GR  - CA23665/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (Guanidines)
RN  - 0 (Ornithine Decarboxylase Inhibitors)
RN  - E524N2IXA3 (Ornithine)
RN  - EC 1.4.3.21 (Amine Oxidase (Copper-Containing))
RN  - EC 4.1.1.- (Carboxy-Lyases)
RN  - EC 4.1.1.17 (Ornithine Decarboxylase)
RN  - SCQ4EZQ113 (pimagedine)
RN  - V10TVZ52E4 (Putrescine)
RN  - ZQN1G5V6SR (Eflornithine)
SB  - IM
MH  - Amine Oxidase (Copper-Containing)/*antagonists & inhibitors/physiology
MH  - Animals
MH  - Carboxy-Lyases/*antagonists & inhibitors
MH  - Cell Line
MH  - Eflornithine
MH  - Guanidines/*pharmacology
MH  - Male
MH  - Ornithine/*analogs & derivatives/pharmacology
MH  - Ornithine Decarboxylase/analysis
MH  - *Ornithine Decarboxylase Inhibitors
MH  - Prostatic Neoplasms/*drug therapy/enzymology
MH  - Putrescine/pharmacology
MH  - Rats
EDAT- 1981/02/01 00:00
MHDA- 1981/02/01 00:01
CRDT- 1981/02/01 00:00
PHST- 1981/02/01 00:00 [pubmed]
PHST- 1981/02/01 00:01 [medline]
PHST- 1981/02/01 00:00 [entrez]
AID - 0304-3835(81)90098-7 [pii]
AID - 10.1016/0304-3835(81)90098-7 [doi]
PST - ppublish
SO  - Cancer Lett. 1981 Feb;11(4):323-30. doi: 10.1016/0304-3835(81)90098-7.