PMID- 6810195
OWN - NLM
STAT- MEDLINE
DCOM- 19821021
LR  - 20190726
IS  - 0028-3908 (Print)
IS  - 0028-3908 (Linking)
VI  - 21
IP  - 5
DP  - 1982 May
TI  - Neurotensin induces catalepsy in mice.
PG  - 465-8
AB  - Intracerebroventricular (i.c.v.) injection of neurotensin (NT) induced catalepsy 
      in mice at doses greater than or equal to 0.02 microgram. The cataleptic effect 
      progressively increased, reaching a maximum at approx. 2 hr after injection. In 
      contrast, the hypothermic effect of neurotensin reached a maximum 1 hr after the 
      injection, and was declining at 2 hr. Not all mice that showed hypothermia also 
      showed catalepsy, and some mice showed catalepsy without hypothermia. Catalepsy 
      induced by intracerebroventricular injection of neurotensin was not significantly 
      correlated with the hypothermia. Furthermore, oxotremorine induced hypothermia 
      without catalepsy. Thus, several lines of evidence indicate that the catalepsy 
      induced by neurotensin is not the consequence of the neurotensin induced 
      hypothermia. Thyrotropin releasing hormone (TRH), injected either 
      intracerebroventricularly with neurotensin, or intraperitoneally before 
      neurotensin abolished the hypothermia but only diminished the catalepsy scores. 
      The cataleptic effect of neurotensin is consistent with its other 
      neuroleptic-like activities.
FAU - Snijders, R
AU  - Snijders R
FAU - Kramarcy, N R
AU  - Kramarcy NR
FAU - Hurd, R W
AU  - Hurd RW
FAU - Nemeroff, C B
AU  - Nemeroff CB
FAU - Dunn, A J
AU  - Dunn AJ
LA  - eng
GR  - MH 25486/MH/NIMH NIH HHS/United States
GR  - MH 34121/MH/NIMH NIH HHS/United States
GR  - MH-32316/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 39379-15-2 (Neurotensin)
RN  - 5Y5F15120W (Thyrotropin-Releasing Hormone)
SB  - IM
MH  - Animals
MH  - Catalepsy/*chemically induced
MH  - Dose-Response Relationship, Drug
MH  - Humans
MH  - Hypothermia/chemically induced
MH  - Injections, Intraventricular
MH  - Male
MH  - Mice
MH  - Neurotensin/administration & dosage/*adverse effects
MH  - Thyrotropin-Releasing Hormone/administration & dosage/pharmacology
MH  - Time Factors
EDAT- 1982/05/01 00:00
MHDA- 1982/05/01 00:01
CRDT- 1982/05/01 00:00
PHST- 1982/05/01 00:00 [pubmed]
PHST- 1982/05/01 00:01 [medline]
PHST- 1982/05/01 00:00 [entrez]
AID - 10.1016/0028-3908(82)90032-6 [doi]
PST - ppublish
SO  - Neuropharmacology. 1982 May;21(5):465-8. doi: 10.1016/0028-3908(82)90032-6.