PMID- 6812389
OWN - NLM
STAT- MEDLINE
DCOM- 19821202
LR  - 20190829
IS  - 0001-6683 (Print)
IS  - 0001-6683 (Linking)
VI  - 51
IP  - 1
DP  - 1982 Jul
TI  - Embryotoxicity of industrial chemicals on the chicken embryo: thiourea 
      derivatives.
PG  - 38-44
AB  - Six thioureas: 1,3-diphenylthiourea (DPTU), 1,3-dibutylthiourea (DBTU), 
      tetramethylthiourea (TEMTU), trimethylthiourea (TRIMTU), 1,3-diethylthiourea 
      (DETU), and 1,3-ethylenethiourea (ETU), were tested, in addition to carbon 
      disulfide, on three day chicken embryos for embryotoxicity. The parameters 
      measured were early deaths, recorded within two days of injection, late deaths of 
      malformed embryos, late deaths of non-malformed embryos, and malformed survivors. 
      The order of total embryotoxicity decreased as follows DBTU greater than DPTU 
      greater than TEMTU greater than TRIMTU greater than DETU greater than ETU. The 
      range for ED50 values for total embryotoxicity was from 0.28 (DBTU) to 4.5 (ETU) 
      mumol/egg. DBTU caused early deaths but no malformations. TEMTU and DPTU were the 
      most potent teratogens.
FAU - Korhonen, A
AU  - Korhonen A
FAU - Hemminki, K
AU  - Hemminki K
FAU - Vainio, H
AU  - Vainio H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Acta Pharmacol Toxicol (Copenh)
JT  - Acta pharmacologica et toxicologica
JID - 0370572
RN  - GYV9AM2QAG (Thiourea)
RN  - S54S8B99E8 (Carbon Disulfide)
SB  - IM
MH  - *Abnormalities, Drug-Induced
MH  - Animals
MH  - Carbon Disulfide/*toxicity
MH  - Chick Embryo
MH  - Dose-Response Relationship, Drug
MH  - Lethal Dose 50
MH  - Thiourea/*analogs & derivatives/toxicity
EDAT- 1982/07/01 00:00
MHDA- 1982/07/01 00:01
CRDT- 1982/07/01 00:00
PHST- 1982/07/01 00:00 [pubmed]
PHST- 1982/07/01 00:01 [medline]
PHST- 1982/07/01 00:00 [entrez]
AID - 10.1111/j.1600-0773.1982.tb01060.x [doi]
PST - ppublish
SO  - Acta Pharmacol Toxicol (Copenh). 1982 Jul;51(1):38-44. doi: 
      10.1111/j.1600-0773.1982.tb01060.x.