PMID- 681744
OWN - NLM
STAT- MEDLINE
DCOM- 19781025
LR  - 20061115
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 121
IP  - 2
DP  - 1978 Aug
TI  - Participation of the humoral immune system in the myeloma-specific 
      transplantation resistance.
PG  - 479-83
AB  - Studies are reported that examine the participation of humoral and cellular 
      responses in the myeloma-specific transplantation resistance induced by 
      preimmunization of BALB/c mice with purified myeloma protein M315. A plasmacytoma 
      spleen colony-forming assay was used to provide a quantitative estimate of the 
      tumor immunity in recipients of unfractionated spleen cells or serum from mice 
      immunized four to seven times with M315. The primary findings were: 1) that the 
      tumor immunity can be transferred by immune spleen cells provided that a boost of 
      M315 is given to adoptive hosts, and 2) that passively transferred serum 
      containing anti-M315 idiotype antibody (a-Id315) can also inhibit tumor growth. 
      Adoptive transfer was successful in the presence of minute amounts of a-Id315, 
      whereas passive transfer required relatively large amounts of activity. The 
      passive transfer experiments involved an extended injection schedule and thus 
      could not discriminate between direct effects of antibody or idiotype-specific 
      humoral substances on tumor cells or inductive effects on the cellular immune 
      system. Experiments examining the properties of the immune elements involved in 
      the transplantation immunity demonstrated that, once established, they are 
      resistant to acute radiation (to 800 R) and cortisone damage.
FAU - Bridges, S H
AU  - Bridges SH
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Myeloma Proteins)
SB  - IM
MH  - Animals
MH  - *Antibody Formation
MH  - Antibody Specificity
MH  - Bone Marrow Cells
MH  - Cell Transformation, Neoplastic
MH  - Cells, Cultured
MH  - Female
MH  - Immunization, Passive
MH  - Immunosuppressive Agents/pharmacology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Myeloma Proteins/*immunology
MH  - Neoplasm Transplantation
MH  - Plasmacytoma/*prevention & control
EDAT- 1978/08/01 00:00
MHDA- 1978/08/01 00:01
CRDT- 1978/08/01 00:00
PHST- 1978/08/01 00:00 [pubmed]
PHST- 1978/08/01 00:01 [medline]
PHST- 1978/08/01 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1978 Aug;121(2):479-83.