PMID- 6817454
OWN - NLM
STAT- MEDLINE
DCOM- 19830225
LR  - 20190727
IS  - 0049-3848 (Print)
IS  - 0049-3848 (Linking)
VI  - 28
IP  - 2
DP  - 1982 Oct 15
TI  - Studies on a form of alpha 2-antiplasmin in plasma which does not interact with 
      the lysine-binding sites in plasminogen.
PG  - 193-9
AB  - A method for the specific determination of a form of alpha 2-antiplasmin which 
      does not interact with the lysine-binding sites in plasminogen (NPB-AP) has been 
      elaborated. Basically, the method is an electroimmnoassay utilizing an 
      intermediate gel, which adsorbs the plasminogen-binding form of alpha 
      2-antiplasmin (PB-AP). The plasma concentration of NPB-AP in healthy individuals 
      was determined as 0.40 mumol/1 +/- 0.14 (SD), constituting 35% +/- 11 (SD) of the 
      total plasma alpha 2-antiplasmin concentration. During extensive plasmapheresis 
      of two pregnant severely D-immunized women the NPB-AP form decreased 
      significantly, while the PB-AP form increased, thus maintaining the total alpha 
      2-antiplasmin at an almost constant level. The increased biosynthesis rate of 
      alpha 2-antiplasmin during the extensive plasmapheresis is thus accounted for by 
      PB-AP indicating this form to be the one primarily synthesized and that the 
      non-binding form is formed in plasma from PB-AP secondarily.
FAU - Wiman, B
AU  - Wiman B
FAU - Nilsson, T
AU  - Nilsson T
FAU - Cedergren, B
AU  - Cedergren B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Thromb Res
JT  - Thrombosis research
JID - 0326377
RN  - 0 (alpha-2-Antiplasmin)
RN  - 9001-91-6 (Plasminogen)
RN  - K3Z4F929H6 (Lysine)
SB  - IM
MH  - Binding Sites
MH  - Female
MH  - Humans
MH  - Lysine/*blood
MH  - Plasmapheresis
MH  - Plasminogen/*metabolism
MH  - Pregnancy
MH  - alpha-2-Antiplasmin/*analysis
EDAT- 1982/10/15 00:00
MHDA- 1982/10/15 00:01
CRDT- 1982/10/15 00:00
PHST- 1982/10/15 00:00 [pubmed]
PHST- 1982/10/15 00:01 [medline]
PHST- 1982/10/15 00:00 [entrez]
AID - 0049-3848(82)90261-4 [pii]
AID - 10.1016/0049-3848(82)90261-4 [doi]
PST - ppublish
SO  - Thromb Res. 1982 Oct 15;28(2):193-9. doi: 10.1016/0049-3848(82)90261-4.