PMID- 6818577
OWN - NLM
STAT- MEDLINE
DCOM- 19830324
LR  - 20190726
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 78
IP  - 3
DP  - 1982
TI  - Effects of monoamine oxidase inhibitors on performance during differential 
      reinforcement of low response rate.
PG  - 214-8
AB  - The effects of three monoamine oxidase inhibitors (MAOI) on performance under a 
      differential-reinforcement-of-low-rate 72-s schedule (DRL 72-s) for water 
      reinforcement were determined. All three drugs (isocarboxazid, iproniazid, 
      phenelzine) reduced response rate and increased reinforcement rate in rats 
      performing under the DRL schedule. Drugs from other classes (alcohol, 
      chlordiazepoxide, morphine, pentobarbital) did not produce similar effects. The 
      ability of MAOI to increase reinforcement rate under a DRL 72-s schedule is 
      similar to that recently reported for tricyclic antidepressants and the two 
      atypical antidepressants mianserin and iprindole. These findings support the 
      contention that the DRL schedule may be useful as a test for identifying new 
      antidepressants and for elucidating the neurochemical effects of antidepressants 
      that are responsible for their therapeutic actions.
FAU - O'Donnell, J M
AU  - O'Donnell JM
FAU - Seiden, L S
AU  - Seiden LS
LA  - eng
GR  - GM-07151/GM/NIGMS NIH HHS/United States
GR  - MH-10562/MH/NIMH NIH HHS/United States
GR  - MH-11191/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Monoamine Oxidase Inhibitors)
RN  - 34237V843T (Isocarboxazid)
RN  - 3K9958V90M (Ethanol)
RN  - 6RZ6XEZ3CR (Chlordiazepoxide)
RN  - 76I7G6D29C (Morphine)
RN  - D892HFI3XA (Iproniazid)
RN  - I4744080IR (Pentobarbital)
RN  - O408N561GF (Phenelzine)
SB  - IM
MH  - Animals
MH  - Chlordiazepoxide/pharmacology
MH  - Conditioning, Operant/*drug effects
MH  - Ethanol/pharmacology
MH  - Iproniazid/pharmacology
MH  - Isocarboxazid/pharmacology
MH  - Male
MH  - Monoamine Oxidase Inhibitors/*pharmacology
MH  - Morphine/pharmacology
MH  - Motivation/drug effects
MH  - Pentobarbital/pharmacology
MH  - Phenelzine/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reinforcement Schedule
EDAT- 1982/01/01 00:00
MHDA- 1982/01/01 00:01
CRDT- 1982/01/01 00:00
PHST- 1982/01/01 00:00 [pubmed]
PHST- 1982/01/01 00:01 [medline]
PHST- 1982/01/01 00:00 [entrez]
AID - 10.1007/BF00428153 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 1982;78(3):214-8. doi: 10.1007/BF00428153.