PMID- 6827408
OWN - NLM
STAT- MEDLINE
DCOM- 19830407
LR  - 20190630
IS  - 0022-3476 (Print)
IS  - 0022-3476 (Linking)
VI  - 102
IP  - 3
DP  - 1983 Mar
TI  - Carbohydrate malabsorption in infants with diarrhea studied with the breath 
      hydrogen test.
PG  - 371-5
AB  - Fermentation of malabsorbed carbohydrate (CHO) reaching the colon was studied by 
      measuring peak breath hydrogen (H2) production between feedings in 28 
      H2-producing hospitalized infants with diarrhea. Patients who required fewer than 
      six days of hospitalization had lower breath H2 values when tested soon after 
      admission than those who required longer stays. Patients hospitalized for more 
      than five days had lower H2 amounts at discharge than on admission. Peak breath 
      H2 values decreased when glucose was substituted for glucose polymers in 
      formulas, or when the formula was fed by continuous drip via a nasogastric tube 
      instead of by orally administered bolus. Glucose-positive and acidic stools were 
      encountered occasionally and were associated with decreased H2 levels. The 
      responses of H2 levels, stool pH, and glucose excretion after changes in patient 
      management or intestinal metabolism of CHO reflect alterations in the balance 
      between proximal intestinal absorption and distal colonic fermentation. 
      Malabsorbed CHO that reaches a competent colon is utilized via microbial 
      conversion, as indicated by high H2 levels, in the absence of glucose-positive 
      and acidic stools. The presence of glucose in the feces or acidic stools 
      indicates an inability of the colon to completely metabolize and absorb CHO or 
      its products of fermentation.
FAU - Lifschitz, C H
AU  - Lifschitz CH
FAU - Irving, C S
AU  - Irving CS
FAU - Gopalakrishna, G S
AU  - Gopalakrishna GS
FAU - Evans, K
AU  - Evans K
FAU - Nichols, B L
AU  - Nichols BL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr
JT  - The Journal of pediatrics
JID - 0375410
RN  - 7YNJ3PO35Z (Hydrogen)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Breath Tests
MH  - *Carbohydrate Metabolism
MH  - Colon/metabolism
MH  - Diarrhea, Infantile/etiology
MH  - Feces/analysis
MH  - Fermentation
MH  - Glucose/analysis
MH  - Humans
MH  - Hydrogen/*analysis
MH  - Infant
MH  - Infant Food
MH  - Intestinal Absorption
MH  - Malabsorption Syndromes/complications/*diagnosis
EDAT- 1983/03/01 00:00
MHDA- 1983/03/01 00:01
CRDT- 1983/03/01 00:00
PHST- 1983/03/01 00:00 [pubmed]
PHST- 1983/03/01 00:01 [medline]
PHST- 1983/03/01 00:00 [entrez]
AID - S0022-3476(83)80651-9 [pii]
AID - 10.1016/s0022-3476(83)80651-9 [doi]
PST - ppublish
SO  - J Pediatr. 1983 Mar;102(3):371-5. doi: 10.1016/s0022-3476(83)80651-9.