PMID- 6828140
OWN - NLM
STAT- MEDLINE
DCOM- 19830407
LR  - 20190617
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 301
IP  - 5901
DP  - 1983 Feb 17-23
TI  - Vasopressin alters female sexual behaviour by acting on the brain independently 
      of alterations in blood pressure.
PG  - 608-10
AB  - Subcutaneous (s.c.) administration of Arg-vasopressin (AVP) prolongs retention of 
      a learned behaviour and elevates arterial blood pressure. Intracerebroventricular 
      (i.c.v.) injection of a thousandfold lower dose of AVP than needed with s.c. 
      injection produces the same behavioural effect, suggesting that AVP acts on the 
      brain to control behaviour. However, as i.c.v. injection of AVP also elevates 
      arterial blood pressure, it was suggested that AVP, and perhaps other peptides as 
      well, influences behaviour indirectly by eliciting a peripheral response, for 
      example blood pressure changes, rather than by acting directly on the brain. The 
      suprachiasmatic nuclei (SCN) of the hypothalamus, a source of vasopressin 
      production, inhibit sexual receptivity in oestradiol-17 beta-treated 
      ovariectomized rats during the light phase of the daily lighting cycle, leading 
      to speculation that vasopressin might inhibit sexual behaviour. Here we report 
      that i.c.v. injections of AVP (1, 4 or 10 ng) inhibit sexual behaviour in 
      receptive rats. This behavioural response is prevented by i.c.v. injection of an 
      antiserum to AVP 30 min before AVP injection. Subcutaneous injection of a high 
      dose of AVP (1 microgram) has no behavioural effect but elevates arterial blood 
      pressure within 30 min of administration. Intracerebroventricular injection of a 
      behaviourally effective dose of AVP (1 ng) has no effect on blood pressure. The 
      results provide direct evidence that AVP can alter behaviour by an action on the 
      brain and independently of its effect on blood pressure.
FAU - Sodersten, P
AU  - Sodersten P
FAU - Henning, M
AU  - Henning M
FAU - Melin, P
AU  - Melin P
FAU - Ludin, S
AU  - Ludin S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 113-79-1 (Arginine Vasopressin)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Animals
MH  - Arginine Vasopressin/administration & dosage/*pharmacology
MH  - Blood Pressure/*drug effects
MH  - Brain/*drug effects
MH  - Estradiol/pharmacology
MH  - Female
MH  - Injections, Intraventricular
MH  - Injections, Subcutaneous
MH  - Posture
MH  - Progesterone/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Sexual Behavior, Animal/*drug effects
EDAT- 1983/02/17 00:00
MHDA- 1983/02/17 00:01
CRDT- 1983/02/17 00:00
PHST- 1983/02/17 00:00 [pubmed]
PHST- 1983/02/17 00:01 [medline]
PHST- 1983/02/17 00:00 [entrez]
AID - 10.1038/301608a0 [doi]
PST - ppublish
SO  - Nature. 1983 Feb 17-23;301(5901):608-10. doi: 10.1038/301608a0.