PMID- 6829448
OWN - NLM
STAT- MEDLINE
DCOM- 19830407
LR  - 20190622
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 51
IP  - 5
DP  - 1983 Mar 1
TI  - Effects of reduced coronary flow on thallium-201 accumulation and release in an 
      in vitro rat heart preparation.
PG  - 891-6
AB  - To study the relation between myocardial thallium-201 (TI-201) uptake, TI-201 
      release, and reduced coronary flow, isolated Langendorff rat hearts (n = 8) were 
      perfused for 3 hours at constant flows ranging from physiologic (12 ml/min) to 
      severely ischemic (1.5 ml/min); thallium activity was monitored with a 
      scintillation probe. Each heart was perfused for 1 hour with thallium buffer, 
      followed by 2 hours with thallium-free buffer at the same flow rate. Accumulation 
      curves for all 4 flows were monoexponential. However, release curves during the 2 
      hours of washout with thallium-free buffer demonstrated a biexponential 
      configuration. The early fast release component decreased with reductions in 
      coronary flow, and the later slow release component did not vary significantly 
      with flow. These data show that thallium clearance has at least 2 components: a 
      rapid (possibly extracellular) component related to coronary flow and a slow 
      (possibly intracellular) component independent of coronary flow. These findings 
      should be useful in providing a better understanding of thallium redistribution 
      observed clinically.
FAU - Goldhaber, S Z
AU  - Goldhaber SZ
FAU - Newell, J B
AU  - Newell JB
FAU - Ingwall, J S
AU  - Ingwall JS
FAU - Pohost, G M
AU  - Pohost GM
FAU - Alpert, N M
AU  - Alpert NM
FAU - Fossel, E T
AU  - Fossel ET
LA  - eng
GR  - HL21751/HL/NHLBI NIH HHS/United States
GR  - HL22290/HL/NHLBI NIH HHS/United States
GR  - HL26215/HL/NHLBI NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 0 (Radioisotopes)
RN  - AD84R52XLF (Thallium)
SB  - IM
MH  - Animals
MH  - Blood Pressure
MH  - *Coronary Circulation
MH  - Heart Rate
MH  - In Vitro Techniques
MH  - Male
MH  - Myocardium/*metabolism
MH  - *Radioisotopes
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Thallium/*metabolism
EDAT- 1983/03/01 00:00
MHDA- 1983/03/01 00:01
CRDT- 1983/03/01 00:00
PHST- 1983/03/01 00:00 [pubmed]
PHST- 1983/03/01 00:01 [medline]
PHST- 1983/03/01 00:00 [entrez]
AID - S0002-9149(83)80150-7 [pii]
AID - 10.1016/s0002-9149(83)80150-7 [doi]
PST - ppublish
SO  - Am J Cardiol. 1983 Mar 1;51(5):891-6. doi: 10.1016/s0002-9149(83)80150-7.