PMID- 6829611
OWN - NLM
STAT- MEDLINE
DCOM- 19830407
LR  - 20071114
IS  - 0148-7299 (Print)
IS  - 0148-7299 (Linking)
VI  - 14
IP  - 1
DP  - 1983 Jan
TI  - Inheritance of immunoglobulin E: genetic model fitting.
PG  - 61-6
AB  - Total serum immunoglobulin E (IgE) concentration was measured on 316 members of 
      five pedigrees selected through breast cancer probands. Sex- and age-adjusted 
      natural logarithm-transformed IgE level was not found to differ between 
      individuals with breast cancer or with cancer of any site and other relatives. 
      Likelihoods of the polygenic and of one-locus, two-allele major gene and mixed 
      models were computed. The analysis provided evidence for the presence of a 
      polygenic component in the determination of IgE; it did not show evidence of a 
      major gene effect.
FAU - Hasstedt, S J
AU  - Hasstedt SJ
FAU - Meyers, D A
AU  - Meyers DA
FAU - Marsh, D G
AU  - Marsh DG
LA  - eng
GR  - AI 13370/AI/NIAID NIH HHS/United States
GR  - CA 28854/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Med Genet
JT  - American journal of medical genetics
JID - 7708900
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Alleles
MH  - Breast Neoplasms/genetics/immunology
MH  - Female
MH  - Genes, Dominant
MH  - Genes, Recessive
MH  - Humans
MH  - Immunoglobulin E/*genetics
MH  - Male
MH  - *Models, Genetic
MH  - Pedigree
MH  - Probability
EDAT- 1983/01/01 00:00
MHDA- 1983/01/01 00:01
CRDT- 1983/01/01 00:00
PHST- 1983/01/01 00:00 [pubmed]
PHST- 1983/01/01 00:01 [medline]
PHST- 1983/01/01 00:00 [entrez]
AID - 10.1002/ajmg.1320140110 [doi]
PST - ppublish
SO  - Am J Med Genet. 1983 Jan;14(1):61-6. doi: 10.1002/ajmg.1320140110.