PMID- 6829782
OWN - NLM
STAT- MEDLINE
DCOM- 19830415
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 244
IP  - 3
DP  - 1983 Mar
TI  - Mechanisms of protection against stroke in stroke-prone spontaneously 
      hypertensive rats.
PG  - H406-12
AB  - The purpose of this study was to examine mechanisms by which sympathetic nerves 
      protect against cerebral hemorrhage and ischemic infarction (i.e., "stroke") in 
      stroke-prone spontaneously hypertensive rats (SHRSP). When unilateral superior 
      cervical ganglionectomy was performed in SHRSP at 1 mo of age, development of 
      cerebral vascular hypertrophy was inhibited and stroke developed only in the 
      denervated hemisphere in 79% of the rats (P less than 0.05). Because "trophic" 
      effects of sympathetic nerves on vascular growth may be less in older animals, 
      unilateral sympathetic denervation was performed in SHRSP at 3 mo of age. The 
      incidence of stroke was similar in the innervated and denervated hemispheres. In 
      another group of rats that had unilateral ganglionectomy at 1 mo, we examined 
      regulation of cerebral blood flow (CBF) when the rats were 4-5 mo of age, before 
      neurologic signs of stroke. CBF, measured with microspheres, was similar in the 
      innervated and denervated hemispheres during control conditions and during 
      maximal vasodilatation produced by bicuculline. In contrast, when mean arterial 
      pressure was raised acutely, CBF increased more in the denervated hemisphere than 
      in the innervated hemisphere. We conclude that 1) in contrast to effects of 
      denervation at 1 mo, sympathetic denervation at 3 mo of age (when trophic effects 
      are less) does not lead to stroke, and 2) chronic denervation impairs the 
      cerebral vasoconstrictor response to acute increases in arterial pressure.
FAU - Sadoshima, S
AU  - Sadoshima S
FAU - Busija, D W
AU  - Busija DW
FAU - Heistad, D D
AU  - Heistad DD
LA  - eng
GR  - HL-06016/HL/NHLBI NIH HHS/United States
GR  - HL-14388/HL/NHLBI NIH HHS/United States
GR  - HL-16066/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - Y37615DVKC (Bicuculline)
SB  - IM
MH  - Animals
MH  - Bicuculline/pharmacology
MH  - Blood Pressure
MH  - Cerebrovascular Circulation/drug effects
MH  - Cerebrovascular Disorders/physiopathology/*prevention & control
MH  - Denervation
MH  - Female
MH  - Hypertension/*complications/physiopathology
MH  - Male
MH  - Microspheres
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Species Specificity
MH  - Sympathetic Nervous System/physiopathology
EDAT- 1983/03/01 00:00
MHDA- 1983/03/01 00:01
CRDT- 1983/03/01 00:00
PHST- 1983/03/01 00:00 [pubmed]
PHST- 1983/03/01 00:01 [medline]
PHST- 1983/03/01 00:00 [entrez]
AID - 10.1152/ajpheart.1983.244.3.H406 [doi]
PST - ppublish
SO  - Am J Physiol. 1983 Mar;244(3):H406-12. doi: 10.1152/ajpheart.1983.244.3.H406.