PMID- 6835176
OWN - NLM
STAT- MEDLINE
DCOM- 19830527
LR  - 20190904
IS  - 0098-1532 (Print)
IS  - 0098-1532 (Linking)
VI  - 11
IP  - 2
DP  - 1983
TI  - Renal cell carcinoma in children.
PG  - 91-8
AB  - Data from four pediatric hospitals concerning 20 children treated for renal cell 
      carcinoma (RCC) from 1964-1978 were reviewed. Median age of the patients (pts) 
      was 11.8 years (range, 14 months-19 years). Twelve were male and eight female; 17 
      were white and three black. Most patients presented with pain and hematuria with 
      or without a palpable mass. An intrarenal tumor was detected at IV urography (17 
      pts), arteriography (2 pts), or at surgery (1 pt). Treatment consisted of 
      nephrectomy in 15 pts, renal biopsy (4 pts), or no surgery (1 pt), followed by 
      chemotherapy (5 pts), radiation therapy (1 pt), or both (7 pts). Ten pts died of 
      distant metastases at a median of one year (range, 0.2 to two years) after 
      diagnosis. The other 10 pts (50%) survive free of relapse at a median of 4 years 
      (range, two to ten years) from diagnosis. Proportions surviving free of recurrent 
      disease two or more years by National Wilms' Tumor Study (NWTS) Group were 5/5 in 
      Group I, 3/7 in Group II, 1/3 in Group III, and 1/5 in Group IV; by age at 
      diagnosis, 6/6 in those under 11 years old and 4/14 in those 11 or older; and by 
      type of surgery, 10/15 who had nephrectomy and 0/5 with limited or no surgery. 
      The data indicate that radiation and chemotherapy had only minor if any 
      influences on relapse-free survival. We conclude that (1) RCC in children is 
      similar to its counterpart in adults; (2) RCC has a worse prognosis than Wilms' 
      tumor except for the earliest stage; (3) nephrectomy alone is adequate treatment 
      for Group I RCC, and (4) young age (less than 11 years old) may be prognostically 
      favorable.
FAU - Raney, R B Jr
AU  - Raney RB Jr
FAU - Palmer, N
AU  - Palmer N
FAU - Sutow, W W
AU  - Sutow WW
FAU - Baum, E
AU  - Baum E
FAU - Ayala, A
AU  - Ayala A
LA  - eng
GR  - CA-11722/CA/NCI NIH HHS/United States
GR  - CA-14489/CA/NCI NIH HHS/United States
GR  - CA-19372/CA/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Med Pediatr Oncol
JT  - Medical and pediatric oncology
JID - 7506654
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Adenocarcinoma/pathology/*therapy
MH  - Adolescent
MH  - Antineoplastic Agents/therapeutic use
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Kidney Neoplasms/pathology/*therapy
MH  - Male
MH  - Neoplasm Metastasis
MH  - Nephrectomy
EDAT- 1983/01/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1983/01/01 00:00
PHST- 1983/01/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1983/01/01 00:00 [entrez]
AID - 10.1002/mpo.2950110205 [doi]
PST - ppublish
SO  - Med Pediatr Oncol. 1983;11(2):91-8. doi: 10.1002/mpo.2950110205.