PMID- 6838956
OWN - NLM
STAT- MEDLINE
DCOM- 19830610
LR  - 20190815
IS  - 0142-9612 (Print)
IS  - 0142-9612 (Linking)
VI  - 4
IP  - 1
DP  - 1983 Jan
TI  - Use of magnetic emulsion as a novel drug carrier for chemotherapeutic agents.
PG  - 49-51
AB  - Magnetic guidance of magnetic emulsion for site specific delivery was 
      investigated in vitro and in vivo. The magnetic emulsion was characterized in 
      vitro for its magnetic responsiveness using a constant flow apparatus, and its 
      high retention by magnetic field was confirmed. After intravenous injection in 
      rat, magnetic emulsions were localized to the predetermined site (lungs) by 
      application of an electromagnet to the lungs. Similarly, 
      1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea (methyl-CCNU) 
      contained in the dispersed oily phase of the emulsions, was also concentrated at 
      the target-site. Such preferential localization by magnetic means suggested that 
      magnetic emulsions could become effective drug carriers with site specificity for 
      the delivery of chemotherapeutic agents in cancer chemotherapy.
FAU - Akimoto, M
AU  - Akimoto M
FAU - Morimoto, Y
AU  - Morimoto Y
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
RN  - 0 (Emulsions)
RN  - 0 (Nitrosourea Compounds)
RN  - 0 (Pharmaceutical Vehicles)
RN  - 13909-09-6 (Semustine)
SB  - IM
MH  - Animals
MH  - Emulsions
MH  - Female
MH  - *Magnetics
MH  - Nitrosourea Compounds/*administration & dosage
MH  - *Pharmaceutical Vehicles
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Semustine/*administration & dosage
EDAT- 1983/01/01 00:00
MHDA- 1983/01/01 00:01
CRDT- 1983/01/01 00:00
PHST- 1983/01/01 00:00 [pubmed]
PHST- 1983/01/01 00:01 [medline]
PHST- 1983/01/01 00:00 [entrez]
AID - 0142-9612(83)90070-4 [pii]
AID - 10.1016/0142-9612(83)90070-4 [doi]
PST - ppublish
SO  - Biomaterials. 1983 Jan;4(1):49-51. doi: 10.1016/0142-9612(83)90070-4.