PMID- 6839514
OWN - NLM
STAT- MEDLINE
DCOM- 19830610
LR  - 20190920
IS  - 0730-0077 (Print)
IS  - 0730-0077 (Linking)
VI  - 5
IP  - 3
DP  - 1983
TI  - Antihypertensive effect of diltiazem in young or adult rats of genetically 
      hypertensive strains.
PG  - 455-68
AB  - The antihypertensive effects of diltiazem were investigated in three different 
      strains of genetically hypertensive rats, i.e. spontaneously hypertensive rats 
      (SHR), stroke prone SHR (SHR-sp) and genetically hypertensive rats (GHR) compared 
      to their respective controls, normotensive Wistar-Kyoto (NT-WKY) and New Zealand 
      strain (NT-NZ). Either adult (3-6 months) or young (4 weeks), conscious rats were 
      used. In adult SHR, SHR-sp and GHR, the percent decrease in blood pressure 
      produced by diltiazem (10, 30 and 100 mg/kg orally (p.o.) or 0.1, 0.3, 1.0 and 
      3.0 mg/kg intravenously (i.v.)) was greater than in NT-WKY or NT-NZ, while no 
      difference was detected in case of hydralazine (5 mg/kg p.o.). In contrast, the 
      reactivity to diltiazem was not different between the young rats bred from the 
      normotensive and hypertensive rats of both the Japanese and the New Zealand 
      strains. It is concluded that diltiazem is a more effective antihypertensive 
      agent in the hypertensive rats than in the normotensive rats. However, the 
      increased reactivity to this compound in the adult hypertensive rats cannot be 
      readily explained by the known pathogenetic factors leading to their 
      hypertension.
FAU - Takata, Y
AU  - Takata Y
FAU - Howes, L G
AU  - Howes LG
FAU - Hutchinson, J S
AU  - Hutchinson JS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clin Exp Hypertens A
JT  - Clinical and experimental hypertension. Part A, Theory and practice
JID - 8207790
RN  - 0 (Benzazepines)
RN  - 26NAK24LS8 (Hydralazine)
RN  - EE92BBP03H (Diltiazem)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Benzazepines/*pharmacology
MH  - Blood Pressure/*drug effects
MH  - Depression, Chemical
MH  - Diltiazem/administration & dosage/*pharmacology/therapeutic use
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Hydralazine/pharmacology/therapeutic use
MH  - Hypertension/*drug therapy
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Time Factors
EDAT- 1983/01/01 00:00
MHDA- 1983/01/01 00:01
CRDT- 1983/01/01 00:00
PHST- 1983/01/01 00:00 [pubmed]
PHST- 1983/01/01 00:01 [medline]
PHST- 1983/01/01 00:00 [entrez]
AID - 10.3109/10641968309069500 [doi]
PST - ppublish
SO  - Clin Exp Hypertens A. 1983;5(3):455-68. doi: 10.3109/10641968309069500.