PMID- 6846171
OWN - NLM
STAT- MEDLINE
DCOM- 19830610
LR  - 20190622
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 51
IP  - 8
DP  - 1983 May 1
TI  - Relation of immediate and delayed thallium-201 distribution to localization of 
      iodine-125 antimyosin antibody in acute experimental myocardial infarction.
PG  - 1428-32
AB  - Thallium-201 (TI-201) distribution in acute experimental myocardial infarction 
      (MI) (n = 18) was compared with cardiac-specific antimyosin Fab (AM-Fab) uptake, 
      a specific marker for myocardial necrosis. When antimyosin was injected 4 hours 
      after ligation with TI-201 administered 23 hours 55 minutes later and measurement 
      of myocardial distribution determined 5 minutes after intravenous administration 
      of TI-201, (1) TI-201 distribution closely correlated with microsphere regional 
      blood flow, and (2) an inverse exponential relation to iodine-125 (I-125) AM-Fab 
      uptake was apparent. In another group of 4 animals, TI-201 and AM-Fab were 
      administered intravenously 4 hours after MI, and 36 hours later myocardial 
      distribution was measured. This delayed TI-201 distribution had a close inverse 
      linear correlation with I-125 AM-Fab uptake. This inverse linear relation also 
      was apparent in 28-hour-old MIs in dogs (n = 4) where collateral circulation had 
      been established. TI-201 was administered intravenously at 27 hours after MI, and 
      TI-201 distribution was determined 1 hour later. The present study demonstrated 
      that whereas immediate TI-201 distribution is flow-limited, delayed TI-201 
      distribution is a marker of cell viability which, due to prolonged circulation 
      time and redistribution, is not flow-limited.
FAU - Khaw, B A
AU  - Khaw BA
FAU - Strauss, H W
AU  - Strauss HW
FAU - Pohost, G M
AU  - Pohost GM
FAU - Fallon, J T
AU  - Fallon JT
FAU - Katus, H A
AU  - Katus HA
FAU - Haber, E
AU  - Haber E
LA  - eng
GR  - HL-17665/HL/NHLBI NIH HHS/United States
GR  - HL-21751/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 0 (Antibodies)
RN  - 0 (Iodine Radioisotopes)
RN  - 0 (Radioisotopes)
RN  - AD84R52XLF (Thallium)
RN  - EC 3.6.4.1 (Myosins)
SB  - IM
MH  - Animals
MH  - Antibodies/*analysis
MH  - Coronary Circulation
MH  - Dogs
MH  - Iodine Radioisotopes
MH  - Myocardial Infarction/*diagnostic imaging/metabolism
MH  - Myocardium/*metabolism
MH  - Myosins/*immunology
MH  - Radioisotopes
MH  - Radionuclide Imaging
MH  - Thallium/*metabolism
MH  - Time Factors
EDAT- 1983/05/01 00:00
MHDA- 1983/05/01 00:01
CRDT- 1983/05/01 00:00
PHST- 1983/05/01 00:00 [pubmed]
PHST- 1983/05/01 00:01 [medline]
PHST- 1983/05/01 00:00 [entrez]
AID - 0002-9149(83)90324-7 [pii]
AID - 10.1016/0002-9149(83)90324-7 [doi]
PST - ppublish
SO  - Am J Cardiol. 1983 May 1;51(8):1428-32. doi: 10.1016/0002-9149(83)90324-7.