PMID- 6850347
OWN - NLM
STAT- MEDLINE
DCOM- 19830715
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 266
IP  - 1
DP  - 1983 Apr 25
TI  - Antagonists of synaptic and amino acid excitation of neurones in the cat spinal 
      cord.
PG  - 83-95
AB  - In the spinal cord of the anaesthetized cat microelectrophoretically administered 
      (+/-)-cis-2,3-piperidine dicarboxylate (2,3-PDA), (+/-)-cis-2,5-piperidine 
      dicarboxylate (2,5-PDA), gamma-D-glutamylglycine (gamma DGG), 
      beta-D-aspartyl-beta-alanine (beta DAA), (+/-)-2-amino-4-phosphonobutyrate 
      (2-APB), (+/-)-2-amino-5-phosphonovalerate (2-APV) and 
      (+/-)-2-amino-7-phosphonoheptanoate (2-APH) were assessed as antagonists of 
      chemical excitation of dorsal horn interneurones and Renshaw cells by 
      N-methyl-D-aspartate (NMDA), L-aspartate, quisqualate (QUIS), kainate and 
      L-glutamate, and of monosynaptic and polysynaptic excitation by impulses in 
      primary afferent fibres of muscle and cutaneous origin. Whereas polysynaptic 
      excitation of interneurones was readily and reversibly depressed by 2-APV, 2-APH, 
      beta DAA, gamma DGG and 2,3-PDA, all of which also reduced excitation by NMDA 
      (and L-aspartate) more than that by QUIS (and L-glutamate), no selective 
      antagonism of monosynaptic excitation could be demonstrated. In particular, 
      2,3-PDA, which depressed excitation by kainate to a greater extent than that by 
      either QUIS or NMDA, appeared to have no effect on monosynaptic excitation. The 
      results support the involvement of L-aspartate as the transmitter of some spinal 
      excitatory interneurones, but none of the antagonists tested were considered 
      suitable for assessing the role of L-glutamate as the transmitter of some spinal 
      primary afferent fibres.
FAU - Peet, M J
AU  - Peet MJ
FAU - Leah, J D
AU  - Leah JD
FAU - Curtis, D R
AU  - Curtis DR
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Amino Acids)
SB  - IM
MH  - Amino Acids/*pharmacology
MH  - Animals
MH  - Cats
MH  - Interneurons/physiology
MH  - Kinetics
MH  - Neurons/drug effects/*physiology
MH  - Spinal Cord/drug effects/*physiology
MH  - Structure-Activity Relationship
MH  - Synapses/drug effects/*physiology
EDAT- 1983/04/25 00:00
MHDA- 1983/04/25 00:01
CRDT- 1983/04/25 00:00
PHST- 1983/04/25 00:00 [pubmed]
PHST- 1983/04/25 00:01 [medline]
PHST- 1983/04/25 00:00 [entrez]
AID - 0006-8993(83)91311-2 [pii]
AID - 10.1016/0006-8993(83)91311-2 [doi]
PST - ppublish
SO  - Brain Res. 1983 Apr 25;266(1):83-95. doi: 10.1016/0006-8993(83)91311-2.