PMID- 6851028
OWN - NLM
STAT- MEDLINE
DCOM- 19830715
LR  - 20190623
IS  - 0009-7322 (Print)
IS  - 0009-7322 (Linking)
VI  - 67
IP  - 6
DP  - 1983 Jun
TI  - Plasma norepinephrine concentration and plasma dopamine-beta-hydroxylase activity 
      in patients with congestive heart failure.
PG  - 1324-9
AB  - The relationship between plasma norepinephrine (NE), epinephrine (E) and 
      dopamine-beta-hydroxylase activity (DBH) was studied in 90 cardiac patients (New 
      York Heart Association [NYHA] classes I-IV), 85 healthy control subjects and 18 
      competitive skiers. The cardiac patients in NYHA classes III and IV had 
      significantly higher NE (p less than 0.001) and lower DBH (p less than 0.001) 
      levels than the controls, whereas the skiers had significantly lower NE (p less 
      than 0.001) and higher DBH (p less than 0.05) levels than the controls. Seven 
      cardiac patients in whom successful cardiac surgery was performed had decreased 
      NE (p less than 0.001) and increased DBH (p less than 0.02), as well as 
      significantly improved NYHA cardiac status (p less than 0.001). These findings 
      demonstrate an inverse relationship between NE and DBH in a population of 
      athletes, normal subjects and cardiac patients; the same inverse relationship 
      holds for these patients when sequential studies are done after a change in 
      cardiac status.
FAU - Minami, M
AU  - Minami M
FAU - Yasuda, H
AU  - Yasuda H
FAU - Yamazaki, N
AU  - Yamazaki N
FAU - Kojima, S
AU  - Kojima S
FAU - Nishijima, H
AU  - Nishijima H
FAU - Matsumura, N
AU  - Matsumura N
FAU - Togashi, H
AU  - Togashi H
FAU - Koike, Y
AU  - Koike Y
FAU - Saito, H
AU  - Saito H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
RN  - 73K4184T59 (Digoxin)
RN  - 7LXU5N7ZO5 (Furosemide)
RN  - EC 1.14.17.1 (Dopamine beta-Hydroxylase)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Digoxin/pharmacology
MH  - Dopamine beta-Hydroxylase/*blood
MH  - Epinephrine/blood
MH  - Female
MH  - Furosemide/pharmacology
MH  - Heart Failure/*blood/metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Norepinephrine/*blood
MH  - Posture
EDAT- 1983/06/01 00:00
MHDA- 1983/06/01 00:01
CRDT- 1983/06/01 00:00
PHST- 1983/06/01 00:00 [pubmed]
PHST- 1983/06/01 00:01 [medline]
PHST- 1983/06/01 00:00 [entrez]
AID - 10.1161/01.cir.67.6.1324 [doi]
PST - ppublish
SO  - Circulation. 1983 Jun;67(6):1324-9. doi: 10.1161/01.cir.67.6.1324.