PMID- 6852119
OWN - NLM
STAT- MEDLINE
DCOM- 19830715
LR  - 20191023
IS  - 0007-5124 (Print)
IS  - 0007-5124 (Linking)
VI  - 32
IP  - 1
DP  - 1983 Jan
TI  - Plasma lipid concentrations and enzyme activities in Nagase analbuminemia rats 
      (NAR).
PG  - 39-46
AB  - Plasma lipid concentrations in NAR (Nagase Analbuminemia Rats) of 4 to 52 weeks 
      old were examined. Plasma enzymes of NAR were also measured in relation to liver 
      function. The concentrations of total lipid, total cholesterol, phospholipid and 
      triglyceride tended to be increased in NAR, while that of non-esterified fatty 
      acid (NEFA) was decreased. The lipid levels (except NEFA) were especially high in 
      female adult NAR, and they were increased with aging. The effect of 17 
      beta-estradiol or testosterone administration on serum lipid concentrations was 
      studied in gonadectomized NAR. Administration of 17 beta-estradiol to 
      gonadectomized NAR increased lipid concentrations, while testosterone 
      administration did not affect lipid levels. The effect of albumin injection on 
      lipid concentrations in female NAR was also investigated. Albumin treatment to 
      female NAR lowered serum lipid concentrations. Plasma glutamic oxaloacetic 
      transaminase, glutamic pyruvic transaminase, lactate dehydrogenase and leucine 
      aminopeptidase activities were higher in NAR than in normal rats. Plasma alkaline 
      phosphatase and cholinesterase activities of NAR were similar to those of normal 
      rats.
FAU - Takahashi, M
AU  - Takahashi M
FAU - Kusumi, K
AU  - Kusumi K
FAU - Shumiya, S
AU  - Shumiya S
FAU - Nagase, S
AU  - Nagase S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Jikken Dobutsu
JT  - Jikken dobutsu. Experimental animals
JID - 1256412
RN  - 0 (Lipids)
RN  - 0 (Serum Albumin)
RN  - 3XMK78S47O (Testosterone)
RN  - 4TI98Z838E (Estradiol)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
RN  - EC 3.4.11.1 (Leucyl Aminopeptidase)
SB  - IM
MH  - Age Factors
MH  - Alanine Transaminase/blood
MH  - Animals
MH  - Aspartate Aminotransferases/blood
MH  - Castration
MH  - Disease Models, Animal
MH  - Estradiol/pharmacology
MH  - Fasting
MH  - Female
MH  - L-Lactate Dehydrogenase/blood
MH  - Leucyl Aminopeptidase/blood
MH  - Lipids/*blood
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Rats, Mutant Strains
MH  - Serum Albumin/*deficiency
MH  - Testosterone/pharmacology
EDAT- 1983/01/01 00:00
MHDA- 1983/01/01 00:01
CRDT- 1983/01/01 00:00
PHST- 1983/01/01 00:00 [pubmed]
PHST- 1983/01/01 00:01 [medline]
PHST- 1983/01/01 00:00 [entrez]
AID - 10.1538/expanim1978.32.1_39 [doi]
PST - ppublish
SO  - Jikken Dobutsu. 1983 Jan;32(1):39-46. doi: 10.1538/expanim1978.32.1_39.