PMID- 686177
OWN - NLM
STAT- MEDLINE
DCOM- 19781027
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 235
IP  - 2
DP  - 1978 Aug
TI  - Determinants of proximal tubular reabsorption as mechanisms of glomerulotubular 
      balance.
PG  - F142-50
AB  - The determinants of absolute proximal reabsorption (APR) were studied in four 
      groups of rats during hydropenia, partial renal vein occlusion (RVO), saline 
      expansion, and RVO after saline expansion. Nephron filtration rate (SNGFR), 
      nephron plasma flow (RPF), APR, and proximal tubule (Pt) peritubular capillary 
      (HPc), and interstitial (HPi) hydrostatic pressures were measured by 
      micropuncture techniques. Subcapsular space (pii) and star peritubular capillary 
      (piE) oncotic pressures were also determined. The peritubular capillary 
      permeability coefficiency (LpAR) and the corresponding effective reabsorptive 
      pressure (ERP) were computed, where APR = LpAR . ERP, and ERP = net reabsorptive 
      pressure across the peritubular capillary. The results indicate that APR 
      correlates best with SNGFR (P less than 0.05), but not with (pii - HPi), RPF, or 
      LpAR. There was a significant relationship between piE and LpAR, where LpAR fell 
      with increases in piE (P less than 0.01). In conclusion, 1) changes in absolute 
      proximal reabsorption correlate best with changes in nephron filtration rate but 
      not with (pii - HPi) across this range of values, 2) changes in efferent oncotic 
      pressure (piiE) correlated inversely with LpAR, and 3) glomerulotubular balance 
      in the proximal tubule can be partially attributed to intraluminal factors.
FAU - Tucker, B J
AU  - Tucker BJ
FAU - Blantz, R C
AU  - Blantz RC
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
SB  - IM
MH  - Animals
MH  - Biological Transport
MH  - Cell Membrane Permeability
MH  - Extracellular Space/*physiology
MH  - Glomerular Filtration Rate
MH  - Kidney Tubules, Proximal/blood supply/*physiology
MH  - Male
MH  - Rats
MH  - Regional Blood Flow
EDAT- 1978/08/01 00:00
MHDA- 1978/08/01 00:01
CRDT- 1978/08/01 00:00
PHST- 1978/08/01 00:00 [pubmed]
PHST- 1978/08/01 00:01 [medline]
PHST- 1978/08/01 00:00 [entrez]
AID - 10.1152/ajprenal.1978.235.2.F142 [doi]
PST - ppublish
SO  - Am J Physiol. 1978 Aug;235(2):F142-50. doi: 10.1152/ajprenal.1978.235.2.F142.